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    Nf1 Neurofibromin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nf1provided by FlyBase
    Official Full Name
    Neurofibromin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015269
    Locus tag
    Dmel_CG8318
    See related
    AllianceGenome:FB:FBgn0015269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8318; Dmel\CG8318; dNf1; dNF1; FBpp0084326; Nf-1; NF-1; nf1; NF1
    Summary
    Enables GTPase activator activity. Involved in several processes, including Ras protein signal transduction; determination of adult lifespan; and learning or memory. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; ganglia; and synaptic neuropil domain. Used to study attention deficit hyperactivity disorder; neurofibromatosis; neurofibromatosis 1; and sleep disorder. Human ortholog(s) of this gene implicated in several diseases, including Watson syndrome; autistic disorder; hematologic cancer (multiple); neurofibromatosis 1 (multiple); and peripheral nervous system neoplasm (multiple). Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nf1 in Genome Data Viewer
    Location:
    96F9-96F9; 3-89 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25983013..25995737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21808735..21821459)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene bride of sevenless Neighboring gene fire dancer Neighboring gene Enhancer of split mdelta, helix-loop-helix Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila. King LB, et al. PLoS Genet, 2020 Jul. PMID 32697780, Free PMC Article
    2. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. Lee SF, et al. Mol Ecol, 2013 May. PMID 23506114, Free PMC Article
    3. Drosophila Contributions towards Understanding Neurofibromatosis 1. Atsoniou K, et al. Cells, 2024 Apr 21. PMID 38667335, Free PMC Article
    4. Neurofibromin 1 mediates sleep depth in Drosophila. Brown EB, et al. PLoS Genet, 2023 Dec. PMID 38091360, Free PMC Article
    5. A particular GAP in mind. Zhu Y, et al. Nat Genet, 2001 Apr. PMID 11279509

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurofibromin 1 mediates sleep depth in Drosophila.
      Title: Neurofibromin 1 mediates sleep depth in Drosophila.
    2. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
      Title: Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
    3. Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
      Title: Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
    4. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.
      Title: Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.
    5. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
      Title: Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
    6. The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1
      Title: Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.
    7. These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1
      Title: The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
    8. memory-related functions of Rut-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.
      Title: A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory.
    9. survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway
      Title: Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling.
    10. Data show that rolled nuclear translocation is regulated by a second mechanism in addition to phosphorylation, and may be held in the cytoplasm for hours.
      Title: Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA surveillance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in perineurial glial growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurofibromin 1
    Names
    CG8318-PB
    CG8318-PC
    CG8318-PD
    CG8318-PE
    CG8318-PF
    Neurofibromatosis-1
    Nf1-PB
    Nf1-PC
    Nf1-PD
    Nf1-PE
    Nf1-PF
    neurofibramatosis-1
    neurofibromatosis 1
    neurofibromatosis factor 1
    neurofibromatosis type 1
    neurofibromin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25983013..25995737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014668.2 → NP_001014668.1  neurofibromin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01399, Q59DT9
      Conserved Domains (4) summary
      cd05130
      Location:1242 → 1575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      cd13313
      Location:1759 → 1868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
      pfam14228
      Location:1931 → 2109
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam13716
      Location:1633 → 1767
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    2. NM_001276049.1 → NP_001262978.1  neurofibromin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI28, O01399
      Conserved Domains (5) summary
      cd05130
      Location:1242 → 1575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:1227 → 1581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13313
      Location:1759 → 1868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
      pfam13716
      Location:1633 → 1759
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      pfam14228
      Location:1931 → 2086
      MOR2-PAG1_mid; Cell morphogenesis central region

    3. NM_001276050.1 → NP_001262979.1  neurofibromin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHX4, O01399
      Conserved Domains (5) summary
      cd05130
      Location:1242 → 1575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:1227 → 1581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13313
      Location:1759 → 1868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
      pfam13716
      Location:1633 → 1759
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      pfam14228
      Location:1931 → 2086
      MOR2-PAG1_mid; Cell morphogenesis central region

    4. NM_170252.3 → NP_733131.2  neurofibromin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01399, Q8IMS2
      Related
      FBpp0084327
      Conserved Domains (4) summary
      cd05130
      Location:1242 → 1575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      cd13313
      Location:1759 → 1868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
      pfam14228
      Location:1931 → 2109
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam13716
      Location:1633 → 1767
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    5. NM_170253.2 → NP_733132.2  neurofibromin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733132.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01397, O01398, Q9VBJ2
      Related
      FBpp0084326, FBtr0084952
      Conserved Domains (4) summary
      cd05130
      Location:1242 → 1575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      cd13313
      Location:1759 → 1868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
      pfam14228
      Location:1931 → 2109
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam13716
      Location:1633 → 1767
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHX4 A0A0B4KHX4
    A0A0B4KI28 A0A0B4KI28
    O01397 O01397
    O01398 O01398
    O01399 O01399
    Q59DT9 Q59DT9
    Q8IMS2 Q8IMS2
    Q95U43 Q95U43
    Q9VBJ2 Q9VBJ2

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