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    Dci Dodecenoyl-CoA delta-isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dciprovided by FlyBase
    Official Full Name
    Dodecenoyl-CoA delta-isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035169
    Locus tag
    Dmel_CG13890
    See related
    AllianceGenome:FB:FBgn0035169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13890; DCI; Dmel\CG13890; PEC1; PECI
    Summary
    Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Involved in defense response to Gram-negative bacterium. Predicted to be located in peroxisome. Is expressed in adult heart; embryonic Malpighian tubule; and organism. Orthologous to several human genes including ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dci in Genome Data Viewer
    Location:
    61D2-61D2; 3-0.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (851346..852673)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (851346..852673)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 61a Neighboring gene Centrosomal protein 290kDa Neighboring gene defective proboscis extension response 20 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of fatty-acid-β-oxidation-related genes extends the lifespan of Drosophila melanogaster. Lee SH, et al. Oxid Med Cell Longev, 2012. PMID 22997544, Free PMC Article
    2. The role of lipid metabolism in aging, lifespan regulation, and age-related disease. Johnson AA, et al. Aging Cell, 2019 Dec. PMID 31560163, Free PMC Article
    3. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Berkey CD, et al. Cell Microbiol, 2009 Mar. PMID 19046341, Free PMC Article
    4. Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster. Li JQ, et al. Mol Genet Genomics, 2019 Dec. PMID 31327054
    5. Drosophila mRNA Localization During Later Development: Past, Present, and Future. Hughes SC, et al. Front Genet, 2019. PMID 30899273, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Dodecenoyl-CoA delta-isomerase
    Names
    CG13890-PA
    Dci-PA
    NP_612065.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      851346..852673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138221.2 → NP_612065.1  Dodecenoyl-CoA delta-isomerase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR61, Q9W0M0
      Related
      FBpp0072484
      Conserved Domains (1) summary
      cd06558
      Location:9 → 197
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR61 Q8MR61
    Q9W0M0 Q9W0M0

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