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    CG17271 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17271provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038829
    Locus tag
    Dmel_CG17271
    See related
    AllianceGenome:FB:FBgn0038829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17271; Dm_3R:88623
    Summary
    Predicted to enable calcium ion binding activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; and gland. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17271 in Genome Data Viewer
    Location:
    93A1-93A1; 3-69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20819129..20821848, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16644851..16647570, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Fancd2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article
    2. A genetic screen in Drosophila for regulators of human prostate cancer progression. Ito S, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25117438
    3. Drep-2 is a novel synaptic protein important for learning and memory. Andlauer TF, et al. Elife, 2014 Nov 13. PMID 25392983, Free PMC Article
    4. Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction. Ravi Ram K, et al. Integr Comp Biol, 2007 Sep. PMID 21672851
    5. Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2. White-Grindley E, et al. PLoS Biol, 2014 Feb. PMID 24523662, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17271-PA
    CG17271-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20819129..20821848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043269.3 → NP_001036734.1  uncharacterized protein Dmel_CG17271, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1A6Y2, Q0KI39
      Conserved Domains (1) summary
      pfam13499
      Location:174 → 262
      EF-hand_7; EF-hand domain pair

    2. NM_142659.2 → NP_650916.1  uncharacterized protein Dmel_CG17271, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZH7, Q9VDI5
      Related
      FBpp0083397
      Conserved Domains (2) summary
      pfam13499
      Location:174 → 250
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:174 → 250
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI39 Q0KI39
    Q8MZH7 Q8MZH7
    Q9VDI5 Q9VDI5

    Gene LinkOut

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