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    Cks85A Cyclin-dependent kinase subunit 85A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cks85Aprovided by FlyBase
    Official Full Name
    Cyclin-dependent kinase subunit 85Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037613
    Locus tag
    Dmel_CG9790
    See related
    AllianceGenome:FB:FBgn0037613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM01344; CG9790; Cks; cks85A; Dmel\CG9790
    Summary
    Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Involved in endomitotic cell cycle. Part of SCF ubiquitin ligase complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cks85A in Genome Data Viewer
    Location:
    85A8-85A9; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8712906..8718456, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4538628..4544178, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44937 Neighboring gene uncharacterized protein Neighboring gene hunchback Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 216 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. Goetze S, et al. PLoS Biol, 2009 Nov. PMID 19885390, Free PMC Article
    2. A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis. Pearson NJ, et al. EMBO Rep, 2005 Nov. PMID 16170306, Free PMC Article
    3. The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation. Dui W, et al. Mol Biol Cell, 2013 Jun. PMID 23552694, Free PMC Article
    4. Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila. Ghorbani M, et al. Dev Biol, 2011 Oct 1. PMID 21827746
    5. Skp2-Cyclin A Interaction Is Necessary for Mitotic Entry and Maintenance of Diploidy. Vasavan B, et al. J Mol Biol, 2024 Apr 15. PMID 38423454

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila.
      Title: Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endomitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase subunit 85A
    Names
    CG9790-PA
    CG9790-PB
    CG9790-PC
    Cks85A-PA
    Cks85A-PB
    Cks85A-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8712906..8718456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275454.1 → NP_001262383.1  Cyclin-dependent kinase subunit 85A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN1
      Conserved Domains (1) summary
      pfam01111
      Location:8 → 73
      CKS; Cyclin-dependent kinase regulatory subunit

    2. NM_001260063.1 → NP_001246992.1  Cyclin-dependent kinase subunit 85A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN1
      Conserved Domains (1) summary
      pfam01111
      Location:8 → 73
      CKS; Cyclin-dependent kinase regulatory subunit

    3. NM_141560.4 → NP_649817.1  Cyclin-dependent kinase subunit 85A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN1
      Related
      FBpp0081430
      Conserved Domains (1) summary
      pfam01111
      Location:8 → 73
      CKS; Cyclin-dependent kinase regulatory subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHN1 Q9VHN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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