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    Fili Fish-lips [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Filiprovided by FlyBase
    Official Full Name
    Fish-lipsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085397
    Locus tag
    Dmel_CG34368
    See related
    AllianceGenome:FB:FBgn0085397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13487; CG34368; CG4054; CT13464; CT32855; Dmel\CG34368; fili
    Old locus tag
    CG13487; CG4054; Dmel_CG13487; Dmel_CG4045; Dmel_CG4054
    Summary
    Involved in regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fili in Genome Data Viewer
    Location:
    58A3-58A4; 2-97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21872030..21946259)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17759535..17833764)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cookie monster Neighboring gene Protein phosphatase N at 58A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Quality Genome Assemblies Reveal Evolutionary Dynamics of Repetitive DNA and Structural Rearrangements in the Drosophila virilis Subgroup. Flynn JM, et al. Genome Biol Evol, 2024 Jan 5. PMID 38159044, Free PMC Article
    2. Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons. Xie Q, et al. Proc Natl Acad Sci U S A, 2019 Aug 6. PMID 31341080, Free PMC Article
    3. Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo. Bali N, et al. MicroPubl Biol, 2019 Dec 18. PMID 32550403, Free PMC Article
    4. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
    5. Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. Dobson AJ, et al. Nat Commun, 2015 Feb 18. PMID 25692519, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fish-lips
    Names
    CG34368-PC
    CG34368-PD
    CG34368-PE
    Fili-PC
    Fili-PD
    Fili-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21872030..21946259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382077.1 → NP_001369108.1  Fish-lips, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7U5
      Conserved Domains (4) summary
      COG4886
      Location:161 → 354
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:75 → 97
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:120 → 180
      LRR_8; Leucine rich repeat

    2. NM_001103932.2 → NP_001097402.1  Fish-lips, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U1A7
      Conserved Domains (4) summary
      cd00116
      Location:79 → 327
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:75 → 97
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:265 → 321
      LRR_8; Leucine rich repeat

    3. NM_137775.2 → NP_611619.2  Fish-lips, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611619.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U1A7
      Conserved Domains (4) summary
      cd00116
      Location:79 → 327
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:75 → 97
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:265 → 321
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6M3Q7U5 A0A6M3Q7U5
    Q5U1A7 Q5U1A7

    Gene LinkOut

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