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    Nak Numb-associated kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35154, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nakprovided by FlyBase
    Official Full Name
    Numb-associated kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015772
    Locus tag
    Dmel_CG10637
    See related
    AllianceGenome:FB:FBgn0015772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10637; Dmel\CG10637; nak
    Summary
    Enables AP-2 adaptor complex binding activity and PTB domain binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of Notch signaling pathway; and regulation of clathrin-dependent endocytosis. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval midgut; gland; and nephrocyte. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nak in Genome Data Viewer
    Location:
    37B7-37B7; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18957732..18968744, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18957732..18968744, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44741 Neighboring gene Betaine-homocysteine S-methyltransferase Neighboring gene Transport and Golgi organization 6 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene Swiprosin-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Li SC, et al. Nat Struct Biol, 1998 Dec. PMID 9846878
    2. Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb. Zwahlen C, et al. EMBO J, 2000 Apr 3. PMID 10747019, Free PMC Article
    3. PTB or not PTB -- that is the question. Yan KS, et al. FEBS Lett, 2002 Feb 20. PMID 11911882
    4. Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Chien CT, et al. Mol Cell Biol, 1998 Jan. PMID 9418906, Free PMC Article
    5. A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome. Alekseyenko AA, et al. Cell, 2008 Aug 22. PMID 18724933, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AP-2 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PTB domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric cell division IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Numb-associated kinase
    Names
    CG10637-PA
    CG10637-PC
    CG10637-PD
    CG10637-PE
    Nak-PA
    Nak-PC
    Nak-PD
    Nak-PE
    NP_001286075.1
    NP_477165.1
    NP_477166.2
    NP_995725.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18957732..18968744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057818.4 → NP_477166.2  Numb-associated kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477166.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U485, Q9VJ30
      Conserved Domains (2) summary
      smart00220
      Location:47 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 319
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    2. NM_057817.4 → NP_477165.1  Numb-associated kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U485, Q9VJ30
      Related
      FBpp0080729
      Conserved Domains (2) summary
      smart00220
      Location:47 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 319
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    3. NM_001299146.1 → NP_001286075.1  Numb-associated kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSQ7, X2J946
      Conserved Domains (2) summary
      smart00220
      Location:47 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 319
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    4. NM_206003.2 → NP_995725.1  Numb-associated kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT38, Q8MSQ7
      Conserved Domains (2) summary
      smart00220
      Location:47 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 319
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT38 Q7KT38
    Q8MSQ7 Q8MSQ7
    Q95TP2 Q95TP2
    Q9U485 Q9U485
    Q9VJ30 Q9VJ30
    X2J946 X2J946

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