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    TpnC25D Troponin C at 25D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TpnC25Dprovided by FlyBase
    Official Full Name
    Troponin C at 25Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031692
    Locus tag
    Dmel_CG6514
    See related
    AllianceGenome:FB:FBgn0031692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey103; BcDNA:RE53289; CG6514; Dmel\CG6514; DmTpnC25D; DmTpnCII; TnC; TNC25D; Tnc5; TpnC II; TPnC25D; TpnCII
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Located in striated muscle thin filament. Is expressed in adult heart. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TpnC25D in Genome Data Viewer
    Location:
    25D1-25D1; 2-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5216701..5219053)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5216701..5219053)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 28d1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene thickveins Neighboring gene transfer RNA:Aspartic acid-GTC 2-1 Neighboring gene transfer RNA:Aspartic acid-GTC 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of the whole troponin C gene repertoire during Drosophila development. Herranz R, et al. Gene Expr Patterns, 2004 Mar. PMID 15161098
    2. Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle. Nongthomba U, et al. J Cell Sci, 2004 Apr 1. PMID 15075240
    3. Evolution of gene sequence in response to chromosomal location. Díaz-Castillo C, et al. Genetics, 2007 Sep. PMID 17890366, Free PMC Article
    4. Diversification and independent evolution of troponin C genes in insects. Herranz R, et al. J Mol Evol, 2005 Jan. PMID 15696366
    5. Hrp59, an hnRNP M protein in Chironomus and Drosophila, binds to exonic splicing enhancers and is required for expression of a subset of mRNAs. Kiesler E, et al. J Cell Biol, 2005 Mar 28. PMID 15781475, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle thin filament HDA PubMed 

    General protein information

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    Preferred Names
    troponin C at 25D
    Names
    CG6514-PA
    CG6514-PB
    CG6514-PC
    TpnC25D-PA
    TpnC25D-PB
    TpnC25D-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5216701..5219053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298691.1 → NP_001285620.1  troponin C at 25D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD70
      Conserved Domains (2) summary
      cd00051
      Location:79 → 141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:80 → 140
      EF-hand_7; EF-hand domain pair

    2. NM_001298690.1 → NP_001285619.1  troponin C at 25D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMT2
      Conserved Domains (1) summary
      PTZ00184
      Location:4 → 146
      PTZ00184; calmodulin; Provisional

    3. NM_135071.4 → NP_608915.2  troponin C at 25D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608915.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMT2
      Related
      FBpp0078699
      Conserved Domains (1) summary
      PTZ00184
      Location:4 → 146
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMT2 Q9VMT2
    X2JD70 X2JD70

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