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    H2.0 Homeodomain protein 2.0 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2.0provided by FlyBase
    Official Full Name
    Homeodomain protein 2.0provided by FlyBase
    Primary source
    FLYBASE:FBgn0001170
    Locus tag
    Dmel_CG11607
    See related
    AllianceGenome:FB:FBgn0001170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11607; Dmel\CG11607
    Summary
    Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Is expressed in several structures, including dorsal epidermis primordium; ectoderm; embryonic dorsal epidermis; embryonic ventral epidermis; and visceral muscle primordium. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See H2.0 in Genome Data Viewer
    Location:
    26B2-26B3; 2-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6013059..6019402, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6013059..6019402, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43866 Neighboring gene beta galactosidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Despite expression in embryonic visceral mesoderm, H2.0 is not essential for Drosophila visceral muscle morphogenesis. Barad M, et al. Dev Genet, 1991. PMID 1678322
    2. Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. Deguchi Y, et al. New Biol, 1991 Apr. PMID 1676597
    3. dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9. Lacin H, et al. Development, 2009 Oct. PMID 19710170, Free PMC Article
    4. Ectoderm induces muscle-specific gene expression in Drosophila embryos. Baker R, et al. Development, 1995 May. PMID 7789269
    5. A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Bodmer R, et al. Development, 1990 Nov. PMID 1982429

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain protein 2.0
    Names
    CG11607-PA
    H2.0-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6013059..6019402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078764.3 → NP_523488.2  homeodomain protein 2.0 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523488.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10035, Q1LYZ9, Q8MS25, Q9VMJ3
      Related
      FBpp0078858
      Conserved Domains (1) summary
      pfam00046
      Location:298 → 351
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10035.2 P10035

    Gene LinkOut

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    Chemical Information
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