nerfin-1 nervous fingers 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nerfin-1provided by FlyBase
Official Full Name: nervous fingers 1provided by FlyBase
Primary source: FLYBASE:FBgn0028999
Locus tag: Dmel_CG13906
See related: AllianceGenome:FB:FBgn0028999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13906; Dmel\CG13906; nerf; nerfin; Nerfin; Nerfin-1; nerfin1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in axon guidance; positive regulation of neuroblast proliferation; and positive regulation of neuron differentiation. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; ganglia; head epidermis primordium; sensory nervous system primordium; and somatic precursor cell. Used to study brain cancer. Orthologous to human INSM1 (INSM transcriptional repressor 1) and INSM2 (INSM transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61D4-61D4; 3-0.5 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (909112..912319)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (909112..912319)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, the authors identify Nerfin-1 as a transcriptional repressor that antagonizes the activity of the Sd-Yki complex by binding to the TEA DNA-binding domain of Sd. Consistent with its biochemical function, ectopic expression of Nerfin-1 results in tissue undergrowth in an Sd-dependent manner.
Title: Nerfin-1 represses transcriptional output of Hippo signaling in cell competition.
Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster central nervous system.
Title: The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.
Our data revealed a new link to understand the underlying mechanism for Nerfin-1 turnover in post-translational level, and provided useful insights in animal development and disease treatment by manipulating the activity of Slimb and Nerfin-1.
Title: The SCF ubiquitin ligase Slimb controls Nerfin-1 turnover in Drosophila.
Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation.
Title: Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity.
(Nerfin-1) locks neurons into differentiation, preventing their reversion into Neuroblasts
Title: The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells.
EvoPrinter facilitates the discovery and analysis of enhancers that control crucial aspects of nerfin-1 expression.
Title: Conserved sequence block clustering and flanking inter-cluster flexibility delineate enhancers that regulate nerfin-1 expression during Drosophila CNS development.
multiple microRNAs play a cooperative role in the post-transcriptional regulation of nerfin-1 mRNA
Title: The Drosophila nerfin-1 mRNA requires multiple microRNAs to regulate its spatial and temporal translation dynamics in the developing nervous system.
Nerfin-1 is essential for the proper expression of robo2, wnt5, derailed, G-oalpha47A, Lar, and futsch genes whose encoded proteins participate in early axon guidance decisions.
Title: Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nervous fingers 1

Names: CG13906-PA; Nerfin-1; nerfin; nerfin 1; nerfin-1-PA; nervous finger-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

909112..912319

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080044.4 → NP_524783.1 nervous fingers 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524783.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3B8

Related

FBpp0072489

Conserved Domains (2) summary

sd00017
Location:252 → 272

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:334 → 356

zf-C2H2; Zinc finger, C2H2 type