U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ufsp2 UFM1 specific peptidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39687, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ufsp2provided by FlyBase
    Official Full Name
    UFM1 specific peptidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036512
    Locus tag
    Dmel_CG16979
    See related
    AllianceGenome:FB:FBgn0036512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16979; Dmel\CG16979; UfSP2
    Summary
    Predicted to enable deUFMylase activity. Predicted to be involved in proteolysis. Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; and organism. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ufsp2 in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15576570..15578674)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15569670..15571774)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Squamous cell carcinoma-related oncogene Neighboring gene drop out Neighboring gene marionette Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. Kang SH, et al. J Biol Chem, 2007 Feb 23. PMID 17182609
    2. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
    3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed M, et al. Nat Genet, 2013 Jun. PMID 23583979, Free PMC Article
    4. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article
    5. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deUFMylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deUFMylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    UFM1 specific peptidase 2
    Names
    CG16979-PA
    Ufsp2-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15576570..15578674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140522.3 → NP_648779.1  UFM1 specific peptidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUR0
      Related
      FBpp0075316
      Conserved Domains (1) summary
      pfam07910
      Location:414 → 599
      Peptidase_C78; Peptidase family C78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUR0.1 Q9VUR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools