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    Ucp4B Uncoupling protein 4B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ucp4Bprovided by FlyBase
    Official Full Name
    Uncoupling protein 4Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031758
    Locus tag
    Dmel_CG18340
    See related
    AllianceGenome:FB:FBgn0031758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18340; Dmel\CG18340; dmUCP4b; DmUCP4B; Ucp 4b; ucp4B; Ucp4b; UCP4B
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in response to cold. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ucp4B in Genome Data Viewer
    Location:
    26A5-26A5; 2-18 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5969859..5971025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5969859..5971025)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43465 Neighboring gene Uncoupling protein 4C Neighboring gene chickadee Neighboring gene eukaryotic translation initiation factor 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880
    2. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
    3. Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. Sokolova IM, et al. FEBS Lett, 2005 Jan 17. PMID 15642337
    4. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. Wu K, et al. FASEB J, 2014 Dec. PMID 25145627
    5. In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury. Constantinou C, et al. Int J Mol Med, 2016 Feb. PMID 26648055, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncoupling protein 4B
    Names
    CG18340-PA
    CG18340-PB
    CG18340-PC
    Ucp4B-PA
    Ucp4B-PB
    Ucp4B-PC
    uncoupling protein 4b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5969859..5971025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135133.3 → NP_608977.1  uncoupling protein 4B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMK0
      Related
      FBpp0078804
      Conserved Domains (2) summary
      PTZ00169
      Location:32 → 306
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:246 → 331
      Mito_carr; Mitochondrial carrier protein

    2. NM_001258975.2 → NP_001245904.1  uncoupling protein 4B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDG1
      Conserved Domains (1) summary
      pfam00153
      Location:138 → 225
      Mito_carr; Mitochondrial carrier protein

    3. NM_164666.3 → NP_723135.1  uncoupling protein 4B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPK1
      Related
      FBpp0078805
      Conserved Domains (1) summary
      pfam00153
      Location:32 → 129
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDG1 M9NDG1
    Q8IPK1 Q8IPK1
    Q9VMK0 Q9VMK0

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