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    snRNP-U1-70K small ribonucleoprotein particle U1 subunit 70K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snRNP-U1-70Kprovided by FlyBase
    Official Full Name
    small ribonucleoprotein particle U1 subunit 70Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016978
    Locus tag
    Dmel_CG8749
    See related
    AllianceGenome:FB:FBgn0016978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    70K; CG8749; Dm70K; Dmel\CG8749; dU1-70K; l(2)02107; snRNP; snRNP 70K; SnRNP-U1-70K; snRNP27D; snRNP70K; snRNPU1-70K; U1; U1 70k; U1 70K; U1 70K snRNP; U1 snRNP; U1-70k; U1-70K; U170K; U1snRNP-70K
    Summary
    Enables mRNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome; oogenesis; and spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including central brain primordium; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See snRNP-U1-70K in Genome Data Viewer
    Location:
    27C7-27D1; 2-24 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6968711..6971737, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6968711..6971737, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Coproporphyrinogen oxidase Neighboring gene Small ubiquitin like modifier Neighboring gene pseudo Neighboring gene uninflatable Neighboring gene long non-coding RNA:CR44326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulation of lipid and carbohydrate storage by the splicing factor gene snRNP-U1-70K in the Drosophila fat body. Shabar H, et al. MicroPubl Biol, 2022. PMID 35655607, Free PMC Article
    2. Human anti-RNP sera contain both human-specific and cross-reactive anti-70K autoantibodies. Henriksson EW, et al. J Autoimmun, 1996 Aug. PMID 8864832
    3. Autoepitope-mapping of the U1-70K protein with human-Drosophila chimeric proteins. Henriksson EW, et al. J Autoimmun, 1997 Dec. PMID 9451595
    4. Key residues revealed in a major conformational epitope of the U1-70K protein. Welin Henriksson E, et al. Proc Natl Acad Sci U S A, 1999 Dec 7. PMID 10588732, Free PMC Article
    5. U1 snRNP regulates cancer cell migration and invasion in vitro. Oh JM, et al. Nat Commun, 2020 Jan 7. PMID 31911652, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. U1 snRNP regulates cancer gene expression, cellmigration and invasion.
      Title: U1 snRNP regulates cancer cell migration and invasion in vitro.
    2. SEX-LETHAL associates with U1 snRNP components in male exon skipping
      Title: Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping.
    3. not essential for viability, nevertheless contribute to an essential U1 snRNP function.
      Title: The Drosophila U1-70K protein is required for viability, but its arginine-rich domain is dispensable.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    small ribonucleoprotein particle U1 subunit 70K
    Names
    CG8749-PA
    CG8749-PC
    U1 snRNP-specific 70K protein
    small nuclear ribonucleoprotein 70K
    snRNP-U1-70K-PA
    snRNP-U1-70K-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6968711..6971737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273244.1 → NP_001260173.1  small ribonucleoprotein particle U1 subunit 70K, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17133, Q564D5, Q9VM56
      UniProtKB/TrEMBL
      M9PC89
      Conserved Domains (3) summary
      COG0724
      Location:97 → 179
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12236
      Location:101 → 188
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:2 → 92
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

    2. NM_057857.5 → NP_477205.1  small ribonucleoprotein particle U1 subunit 70K, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17133, Q564D5, Q9VM56
      UniProtKB/TrEMBL
      M9PC89
      Related
      FBpp0078983
      Conserved Domains (3) summary
      COG0724
      Location:97 → 179
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12236
      Location:101 → 188
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:2 → 92
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC89 M9PC89
    P17133.2 P17133

    Gene LinkOut

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