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    Gfat2 Glutamine:fructose-6-phosphate aminotransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfat2provided by FlyBase
    Official Full Name
    Glutamine:fructose-6-phosphate aminotransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039580
    Locus tag
    Dmel_CG1345
    See related
    AllianceGenome:FB:FBgn0039580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1345; Dmel/GFAT2; Dmel\CG1345; gfat2; GFAT2
    Summary
    Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gfat2 in Genome Data Viewer
    Location:
    98C4-98C4; 3-95 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28337019..28339765, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24162741..24165487, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene La related protein Neighboring gene antisense RNA:CR46104 Neighboring gene antisense RNA:CR46105 Neighboring gene Moca-cyp Neighboring gene Odorant receptor 98b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner. Graack HR, et al. Biochem J, 2001 Dec 1. PMID 11716769, Free PMC Article
    2. Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions. Chen P, et al. Fly (Austin), 2020 Mar-Dec. PMID 32615907, Free PMC Article
    3. Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Niccoli T, et al. Curr Biol, 2016 Sep 12. PMID 27524482, Free PMC Article
    4. Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals. Liu X, et al. J Biol Chem, 2024 Feb. PMID 38159854, Free PMC Article
    5. New local potential useful for genome annotation and 3D modeling. Chandonia JM, et al. J Mol Biol, 2003 Sep 26. PMID 12972255

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
      Title: Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutamine:fructose-6-phosphate aminotransferase 2
    Names
    CG1345-PA
    Gfat2-PA
    glucose-fructose amidotransferase 2
    NP_651617.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28337019..28339765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143360.4 → NP_651617.1  Glutamine:fructose-6-phosphate aminotransferase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAW3
      Related
      FBpp0084666
      Conserved Domains (4) summary
      PLN02981
      Location:1 → 683
      PLN02981; glucosamine:fructose-6-phosphate aminotransferase
      cd00714
      Location:2 → 285
      GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
      cd05008
      Location:370 → 495
      SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
      cd05009
      Location:528 → 681
      SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAW3 Q9VAW3

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