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    Iru Iruka [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iruprovided by FlyBase
    Official Full Name
    Irukaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037653
    Locus tag
    Dmel_CG11982
    See related
    AllianceGenome:FB:FBgn0037653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11982; Dmel\CG11982
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination. Is expressed in organism. Orthologous to several human genes including RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Iru in Genome Data Viewer
    Location:
    85C2-85C2; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9006456..9008030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4832178..4833752)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta3 subunit Neighboring gene uncharacterized protein Neighboring gene Potassium channel modulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Kobayashi H, et al. Mol Cell, 2019 Jan 3. PMID 30503771
    2. VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. Kobayashi H, et al. Cell Rep, 2019 Jul 30. PMID 31365860
    3. E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein. Weiler KS. Genetics, 2007 Sep. PMID 17660546, Free PMC Article
    4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    iruka
    Names
    CG11982-PA
    Iru-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9006456..9008030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141602.4 → NP_649859.1  iruka [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHI7
      Related
      FBpp0081445
      Conserved Domains (3) summary
      COG5243
      Location:253 → 372
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16667
      Location:252 → 294
      RING-H2_RNF126_like; RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
      pfam14369
      Location:16 → 46
      zinc_ribbon_9; zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHI7.1 Q9VHI7

    Gene LinkOut

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