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    cu curled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cuprovided by FlyBase
    Official Full Name
    curledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261808
    Locus tag
    Dmel_CG31299
    See related
    AllianceGenome:FB:FBgn0261808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31299; CG4782; CG4796; Dmel\CG31299; no; no(cu); noc; noct; Noct; nocturnin
    Summary
    Enables NADP phosphatase activity and NADPH phosphatase activity. Involved in NADP metabolic process; locomotor rhythm; and response to light stimulus. Located in cytoplasm. Is expressed in several structures, including DN3 neuron; adult brain; adult head; embryonic/larval salivary gland; and gut section. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    86D7-86D7; 3-50 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11197592..11208633)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7023314..7034355)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 303 member A1 Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit C Neighboring gene Translationally controlled tumor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Malformed, a mutation of Drosophila melanogaster producing mirror-image duplication of a portion of the orbit. Baker WK, et al. Dev Biol, 1977 May. PMID 405263
    2. The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled). Estrella MA, et al. Nat Commun, 2019 May 30. PMID 31147539, Free PMC Article
    3. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Carthew RW, et al. Cell, 1990 Nov 2. PMID 2146028
    4. A gene responsible for a cuticular hydrocarbon polymorphism in Drosophila melanogaster. Coyne JA, et al. Genet Res, 1999 Jun. PMID 10425916
    5. Cytogenetic localization by variation in electrophoretic allozyme phenotype: Drosophila Odh. Clark BA. Biochem Genet, 1983 Apr. PMID 6407472

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    curled
    Names
    CG31299-PC
    CG31299-PD
    CG31299-PE
    CG31299-PF
    CG31299-PG
    CG31299-PH
    cu-PC
    cu-PD
    cu-PE
    cu-PF
    cu-PG
    cu-PH
    dnocturnin
    nocturin
    nocturnin
    NP_001097745.1
    NP_001097746.1
    NP_001097747.1
    NP_001262471.1
    NP_731539.2
    NP_731540.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11197592..11208633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169375.2 → NP_731540.2  curled, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731540.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PPK5
      Conserved Domains (1) summary
      cl00490
      Location:111 → 408
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_169374.2 → NP_731539.2  curled, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731539.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHA6
      Conserved Domains (1) summary
      cl00490
      Location:151 → 448
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. NM_001104277.2 → NP_001097747.1  curled, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3ZAP4
      Conserved Domains (1) summary
      cl00490
      Location:116 → 413
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. NM_001275542.1 → NP_001262471.1  curled, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH43
      Conserved Domains (1) summary
      cl00490
      Location:89 → 386
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. NM_001104276.2 → NP_001097746.1  curled, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH43, A0A0C4DHA6, A8JQX3, C0PPK5, Q3ZAP4, Q6AWF6, Q8MTZ6
      Conserved Domains (1) summary
      cl00490
      Location:312 → 609
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. NM_001104275.3 → NP_001097745.1  curled, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MTZ6
      Conserved Domains (1) summary
      cl00490
      Location:119 → 416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JQX3.1 A8JQX3

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