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    SerRS-m Seryl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41862, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SerRS-mprovided by FlyBase
    Official Full Name
    Seryl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021750
    Locus tag
    Dmel_CG4938
    See related
    AllianceGenome:FB:FBgn0021750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aat-Ser; Aats-ser; CG4938; Dmel\CG4938; DmSerRS2; DmSRS2; dSARS; SerRS; SerRS2; SRS
    Summary
    Contributes to serine-tRNA ligase activity. Involved in mitochondrial seryl-tRNA aminoacylation. Part of serine-tRNA ligase complex. Is expressed in embryonic/larval salivary gland and organism. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SerRS-m in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15340667..15343218)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11166389..11168940)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase Neighboring gene Surfeit 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease. Dulic M, et al. Life (Basel), 2024 Jan 15. PMID 38255739, Free PMC Article
    2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
    3. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
    4. Selenium metabolism in Drosophila. Characterization of the selenocysteine tRNA population. Zhou X, et al. J Biol Chem, 1999 Jun 25. PMID 10373487
    5. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Armes N, et al. Mol Cell Biol, 1996 Oct. PMID 8816471, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to serine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial seryl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in seryl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of serine-tRNA ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Seryl-tRNA synthetase, mitochondrial
    Names
    CG4938-PA
    CG4938-PB
    SerRS-m-PA
    SerRS-m-PB
    seryl-tRNA synthetase
    NP_001262599.1
    NP_524365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15340667..15343218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275670.1 → NP_001262599.1  Seryl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF85
      Conserved Domains (2) summary
      COG0172
      Location:60 → 404
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl00268
      Location:100 → 394
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    2. NM_079641.3 → NP_524365.1  Seryl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF85
      Related
      FBpp0082542
      Conserved Domains (2) summary
      COG0172
      Location:60 → 404
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl00268
      Location:100 → 394
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18406 O18406
    Q9VF85 Q9VF85

    Gene LinkOut

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