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    ND-B18 NADH dehydrogenase (ubiquinone) B18 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B18provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B18 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030605
    Locus tag
    Dmel_CG5548
    See related
    AllianceGenome:FB:FBgn0030605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5548; Dmel\CG5548; dNDUFB7; NB8M; NDUFB7
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B18 in Genome Data Viewer
    Location:
    13A8-13A8; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15063733..15064926)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14957766..14958959)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene highwire Neighboring gene ben Neighboring gene uncharacterized protein Neighboring gene opossum Neighboring gene doppelganger von brummer Neighboring gene Lipid storage droplet-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex-I-ty in aging. Hur JH, et al. J Bioenerg Biomembr, 2014 Aug. PMID 24961226, Free PMC Article
    2. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    3. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
    4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    5. An antibody toolbox to track complex I assembly defines AIF's mitochondrial function. Murari A, et al. J Cell Biol, 2020 Oct 5. PMID 32936885, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B18 subunit
    Names
    CG5548-PA
    CG5548-PB
    CG5548-PC
    NADH ubiquinone oxidoreductase B18
    NADH-ubiquinone oxidoreductase B18 subunit
    NADH:ubiquinone oxidoreductase B18 subunit
    ND-B18-PA
    ND-B18-PB
    ND-B18-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15063733..15064926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298331.1 → NP_001285260.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ0
      Conserved Domains (1) summary
      pfam05676
      Location:38 → 100
      NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

    2. NM_001298330.1 → NP_001285259.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ0
      Conserved Domains (1) summary
      pfam05676
      Location:38 → 100
      NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

    3. NM_132765.2 → NP_572993.1  NADH dehydrogenase (ubiquinone) B18 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXZ0
      Related
      FBpp0073777
      Conserved Domains (1) summary
      pfam05676
      Location:38 → 100
      NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXZ0 Q9VXZ0

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