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    Socs36E Suppressor of cytokine signaling at 36E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35085, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Socs36Eprovided by FlyBase
    Official Full Name
    Suppressor of cytokine signaling at 36Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041184
    Locus tag
    Dmel_CG15154
    See related
    AllianceGenome:FB:FBgn0041184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.2; CG15154; clone 2.2; Dmel\CG15154; dmSocs36E; dSOCS; SCOS36E; Socs; SOCS; Socs36; SOCS36; socs36e; socs36E; Socs36e; SocS36E; SOCS36E; socs60E1
    Summary
    Enables cytokine receptor binding activity and sevenless binding activity. Involved in several processes, including border follicle cell migration; negative regulation of signal transduction; and wing disc morphogenesis. Is expressed in several structures, including cardiogenic mesoderm; follicle cell; gut section; mesoderm; and muscle cell. Orthologous to several human genes including SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Socs36E in Genome Data Viewer
    Location:
    36E6-36E6; 2-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18138675..18152417, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18138675..18152417, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 36b Neighboring gene kelch Neighboring gene long non-coding RNA:CR44478 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster. Moskalev A, et al. BMC Syst Biol, 2019 Mar 5. PMID 30836998, Free PMC Article
    2. Systematic screen of chemotherapeutics in Drosophila stem cell tumors. Markstein M, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616500, Free PMC Article
    3. Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway. Karsten P, et al. Mech Dev, 2002 Sep. PMID 12204282
    4. Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity. Almudi I, et al. J Cell Sci, 2010 Nov 15. PMID 20980384
    5. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Bach EA, et al. Gene Expr Patterns, 2007 Jan. PMID 17008134

    See all (230) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. contributes mechanistic insight to a Jak/STAT regulatory genetic circuit, and suggests that Socs36E regulates Jak/STAT signaling via a Cul2-dependent mechanism, as well as by a Cullin-independent manner, in vivo
      Title: Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber.
    2. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.
      Title: Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.
    3. The Drosophila JAK/STAT pathway regulator SOCS36E functions via two independent mechanisms.
      Title: Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.
    4. Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
      Title: Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
    5. study found the JAK-STAT signaling target & inhibitor, SOCS36E, is required for germline stem cell maintenance; SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells
      Title: JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche.
    6. Socs36E constitutes a novel partially redundant feedback mechanism that contributes to the robustness of R7 specification. The SOCS family of adaptor proteins may have evolved as modulators of specific signaling pathways.
      Title: SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development.
    7. cloning and expression pattern during embryonic and imaginal disc development
      Title: Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway.
    8. SOCS36E suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc
      Title: SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sevenless binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell dedifferentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in haltere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of R7 cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sevenless signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in notum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling at 36E
    Names
    CG15154-PA
    CG15154-PC
    CG15154-PD
    Socs36E-PA
    Socs36E-PC
    Socs36E-PD
    suppressor of cytokine signaling
    suppressor of cytokine signaling 36E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18138675..18152417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273605.2 → NP_001260534.1  suppressor of cytokine signaling at 36E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P82, Q8WTC3, Q9VJA1
      Conserved Domains (2) summary
      cl02533
      Location:575 → 626
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl15255
      Location:463 → 563
      SH2; Src homology 2 (SH2) domain

    2. NM_165243.3 → NP_724096.1  suppressor of cytokine signaling at 36E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P82, Q8WTC3, Q9VJA1
      Related
      FBpp0080593
      Conserved Domains (2) summary
      cl02533
      Location:575 → 626
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl15255
      Location:463 → 563
      SH2; Src homology 2 (SH2) domain

    3. NM_078869.6 → NP_523593.5  suppressor of cytokine signaling at 36E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523593.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P82, Q8INY1
      Conserved Domains (2) summary
      cl02533
      Location:575 → 626
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl15255
      Location:463 → 563
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P82 Q86P82
    Q8INY1 Q8INY1
    Q8WTC2 Q8WTC2
    Q9VJA1 Q9VJA1

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