Pcsk1 proprotein convertase subtilisin/kexin type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcsk1provided by RGD
Official Full Name: proprotein convertase subtilisin/kexin type 1provided by RGD
Primary source: RGD:3272
See related: EnsemblRapid:ENSRNOG00000011107 AllianceGenome:RGD:3272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BDP; PC1; PC3
Summary: Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to interleukin-1. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 49.8), Spleen (RPKM 29.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (6130045..6176974)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (4395543..4442434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (91450162..91497091, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2.
Title: The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
PC1/3 as an important regulator of vesicle trafficking and secretion in macrophages.
Title: Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
Chronic ethanol exposure decreases prohormone convertase (pc1/3) immunoreactivity in brain.
Title: Decreased immunoreactivity of the polypeptide precursor pro-opiomelanocortin (POMC) and the prohormone convertase pc1/3 after chronic ethanol exposure in Sprague-Dawley rats.
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin.
Title: Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach.
Title: Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach.
PC1/PC3 and PC2 (specific to neural and endocrine cells) are absent in undifferentiated bone marrow stromal stem cells, their expression is initiated upon the induction of differentiation
Title: Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs).
our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin
Title: Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
Leptin regulates hypothalamic PC1 expression and requires prohormone processing into mature peptides.
Title: Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
Title: Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
proGHRH is initially cleave by furin at preproGHRH29-30, followed by a second cleavage at preproGHRH74 primarily by PC1 to generate GHRH and GHRH-RP peptides, respectively.
Title: Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

AU049217 (e-PCR)
- UniSTS:145665

Pcsk1 (e-PCR), detects polymorphism
- UniSTS:532489

M58589 (e-PCR)
- UniSTS:124959

BE119208 (e-PCR)
- UniSTS:249132

D1S3695 (e-PCR)
- UniSTS:474273

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in insulin processing	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide hormone processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to chlorate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuroendocrine convertase 1

Names: NEC 1; Protein convertase subtilisin / kexin, type I; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1

NP_058787.1

EC 3.4.21.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017091.2 → NP_058787.1 neuroendocrine convertase 1 precursor

See identical proteins and their annotated locations for NP_058787.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002, M76705, M83745

UniProtKB/Swiss-Prot

P28840

UniProtKB/TrEMBL

A6I4E7

Related

ENSRNOP00000015185.2, ENSRNOT00000015185.5

Conserved Domains (4) summary

cd04059
Location:121 → 415

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

pfam01483
Location:504 → 591

P_proprotein; Proprotein convertase P-domain

pfam12177
Location:712 → 750

Proho_convert; Prohormone convertase enzyme

pfam16470
Location:34 → 110

S8_pro-domain; Peptidase S8 pro-domain