Vkor Vitamin-K epoxide reductase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vkorprovided by FlyBase
Official Full Name: Vitamin-K epoxide reductaseprovided by FlyBase
Primary source: FLYBASE:FBgn0053544
Locus tag: Dmel_CG33544
See related: AllianceGenome:FB:FBgn0053544
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BP1071; CG33544; Dmel\CG33544; HDC06808; VKORC1
Summary: Predicted to enable vitamin-K-epoxide reductase (warfarin-sensitive) activity. Predicted to be involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 2 and warfarin resistance. Orthologous to several human genes including VKORC1 (vitamin K epoxide reductase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16778365..16778994)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12665870..12666499)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IEA Inferred from Electronic Annotation more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in vitamin K metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K metabolic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin K metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

NP_001014533.1

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The following sections contain reference sequences that belong to a specific genome build. Explain