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    nan nanchung [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39571, updated on 9-Dec-2024

    Summary

    Official Symbol
    nanprovided by FlyBase
    Official Full Name
    nanchungprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036414
    Locus tag
    Dmel_CG5842
    See related
    AllianceGenome:FB:FBgn0036414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5842; CT18317; Dmel\CG5842; DmNan; Iav; Nan; NAN; OCR; TRPV
    Summary
    Enables mechanosensitive monoatomic cation channel activity. Contributes to calcium channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception; negative gravitaxis; and startle response. Part of calcium channel complex. Is active in plasma membrane. Is expressed in several structures, including adult antennal lobe local neurons; chordotonal neurons; longitudinal vein; organism subdivision; and sense organ. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPV3 (transient receptor potential cation channel subfamily V member 3); TRPV5 (transient receptor potential cation channel subfamily V member 5); and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nan in Genome Data Viewer
    Location:
    70D3-70D3; 3-42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14186249..14189648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14179349..14182748, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45887 Neighboring gene Dichaete Neighboring gene nuclear fallout Neighboring gene saturn Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to calcium channel activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables mechanosensitive monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mechanosensitive monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to auditory stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to humidity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nanchung
    Names
    CG5842-PA
    CG5842-PB
    NANCHUNG
    nan-PA
    nan-PB
    transient receptor potential vanilloid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14186249..14189648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140439.3NP_648696.2  nanchung, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648696.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z077, Q9VUD5
      Related
      FBpp0088509
      Conserved Domains (4) summary
      cd00204
      Location:178329
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:519727
      Ion_trans; Ion transport protein
      pfam12796
      Location:184311
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:179229
      ANK; ANK repeat [structural motif]
    2. NM_001274904.1NP_001261833.1  nanchung, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI57
      Conserved Domains (4) summary
      cd00204
      Location:178329
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:519727
      Ion_trans; Ion transport protein
      pfam12796
      Location:184311
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:179229
      ANK; ANK repeat [structural motif]