Eaat1 Excitatory amino acid transporter 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Eaat1provided by FlyBase
Official Full Name: Excitatory amino acid transporter 1provided by FlyBase
Primary source: FLYBASE:FBgn0026439
Locus tag: Dmel_CG3747
See related: AllianceGenome:FB:FBgn0026439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AF001784; CG3747; dEAAT; dEaat1; dEAAT1; Dglt-1; Dglut-1; Dmel\CG3747; EAAT; Eaat 1; eaat1; EAAT1; GLUT
Summary: Enables L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and glutamate:sodium symporter activity. Involved in several processes, including adult locomotory behavior; determination of adult lifespan; and regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction. Located in terminal bouton. Colocalizes with neuromuscular junction. Is expressed in several structures, including adult head; adult heart; brain; glial cell; and synaptic neuropil domain. Used to study epilepsy; episodic ataxia type 6; and neurodegenerative disease. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria; episodic ataxia type 6; schizophrenia 18; and spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to several human genes including SLC1A6 (solute carrier family 1 member 6) and SLC1A7 (solute carrier family 1 member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 30A8-30A8; 2-35 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9333567..9341925)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9333567..9341925)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ion-coupling mechanism of human excitatory amino acid transporters.
Title: The ion-coupling mechanism of human excitatory amino acid transporters.
A Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses.
Title: A tripartite synapse model in Drosophila.
Eaat1 expression is promoted by Fringe-mediated neuron-glial communication during development and suggest that Eaat1 plays an essential role in regulating central nervous system neural circuits that control locomotion in Drosophila
Title: Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.
Terminal glial differentiation involves regulated expression of the excitatory amino acid transporters in the Drosophila embryonic CNS.
Title: Terminal glial differentiation involves regulated expression of the excitatory amino acid transporters in the Drosophila embryonic CNS.
dEAAT1 is present at the adult, but surprisingly not at embryonic and larval NMJ, suggesting a physiological maturation of the junction during metamorphosis
Title: Physiological requirement for the glutamate transporter dEAAT1 at the adult Drosophila neuromuscular junction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in adult locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aspartate transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: excitatory amino acid transporter 1

Names: CG3747-PA; CG3747-PB; CG3747-PC; CG3747-PD; CG3747-PE; CG3747-PF; Eaat1-PA; Eaat1-PB; Eaat1-PC; Eaat1-PD; Eaat1-PE; Eaat1-PF; drosophila glutamate transporter-1; glutamate transporter; sodium-dependent excitatory amino acid transporter 1; sodium-dependent glutamate transporter; sodium-excitatory-glutamate-cotransporter; vesicular glutamate transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9333567..9341925

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382081.1 → NP_001369122.1 excitatory amino acid transporter 1, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EIE0, Q5BIC0

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family
NM_001382082.1 → NP_001369123.1 excitatory amino acid transporter 1, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EJK0, Q5BIC0

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family
NM_058080.4 → NP_477428.1 excitatory amino acid transporter 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477428.1

Status: REVIEWED

UniProtKB/TrEMBL

O77062, Q5BIC0

Related

FBpp0079401

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family
NM_001201822.2 → NP_001188751.1 excitatory amino acid transporter 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188751.1

Status: REVIEWED

UniProtKB/TrEMBL

O77062, Q5BIC0

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family
NM_164853.3 → NP_723454.1 excitatory amino acid transporter 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723454.1

Status: REVIEWED

UniProtKB/TrEMBL

O77062, Q5BIC0

Related

FBpp0079400

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family
NM_164854.3 → NP_723455.1 excitatory amino acid transporter 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723455.1

Status: REVIEWED

UniProtKB/TrEMBL

O77062, Q5BIC0

Related

FBpp0079402

Conserved Domains (1) summary

pfam00375
Location:20 → 449

SDF; Sodium:dicarboxylate symporter family