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    prom prominin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    promprovided by FlyBase
    Official Full Name
    promininprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259210
    Locus tag
    Dmel_CG42310
    See related
    AllianceGenome:FB:FBgn0259210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30164; CG30165; CG30166; CG42310; CG4556; Dmel\CG42310; eyc; Prom
    Old locus tag
    Dmel_CG30164; Dmel_CG30165; Dmel_CG30166
    Summary
    Involved in rhabdomere development. Located in rhabdomere microvillus. Is expressed in adult head and photoreceptor neurons. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1) and PROM2 (prominin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prom in Genome Data Viewer
    Location:
    60C8-60C8; 2-106 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24415410..24428387, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20302933..20315910, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imaging the Drosophila retina: zwitterionic buffers PIPES and HEPES induce morphological artifacts in tissue fixation. Nie J, et al. BMC Dev Biol, 2015 Feb 3. PMID 25645690, Free PMC Article
    2. Preserving cell shape under environmental stress. Cook B, et al. Nature, 2008 Mar 20. PMID 18297055, Free PMC Article
    3. Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates. Yablonovitch AL, et al. Nat Commun, 2017 Nov 17. PMID 29146998, Free PMC Article
    4. A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from fused to open rhabdoms. Mahato S, et al. Dev Biol, 2018 Nov 15. PMID 30243673
    5. Evolutionary biology: fly eyes get the whole picture. Moses K. Nature, 2006 Oct 12. PMID 17035985

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the physiological role of Prominin is conserved between rhabdomeric and ciliated photoreceptor cells
      Title: Cross species analysis of Prominin reveals a conserved cellular role in invertebrate and vertebrate photoreceptor cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in rhabdomere microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prominin
    Names
    CG42310-PB
    CG42310-PC
    CG42310-PD
    CG42310-PE
    eyes closed
    prom-PB
    prom-PC
    prom-PD
    prom-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24415410..24428387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144281.2 → NP_001137753.1  prominin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AVW1, Q06PM6
      Conserved Domains (4) summary
      pfam05478
      Location:77 → 826
      Prominin; Prominin
      pfam08648
      Location:857 → 1011
      DUF1777; Protein of unknown function (DUF1777)
      pfam12300
      Location:857 → 960
      DUF3628; Protein of unknown function (DUF3628)
      pfam12871
      Location:852 → 900
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    2. NM_001299914.1 → NP_001286843.1  prominin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGM0
      Conserved Domains (2) summary
      pfam05478
      Location:73 → 826
      Prominin; Prominin
      pfam12300
      Location:857 → 960
      DUF3628; Protein of unknown function (DUF3628)

    3. NM_001144282.2 → NP_001137754.1  prominin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZQ3
      Conserved Domains (1) summary
      pfam05478
      Location:73 → 826
      Prominin; Prominin

    4. NM_166671.2 → NP_726444.2  prominin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726444.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06PM6, Q8MLN9
      Conserved Domains (2) summary
      pfam05478
      Location:77 → 826
      Prominin; Prominin
      pfam12871
      Location:852 → 900
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGM0 A0A0B4LGM0
    A0AVW1 A0AVW1
    B7YZQ3 B7YZQ3
    Q06PM6 Q06PM6
    Q8MLN9 Q8MLN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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