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    Agpat1 1-Acylglycerol-3-phosphate O-acyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agpat1provided by FlyBase
    Official Full Name
    1-Acylglycerol-3-phosphate O-acyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030421
    Locus tag
    Dmel_CG3812
    See related
    AllianceGenome:FB:FBgn0030421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AGPAT; AGPAT1; AGPAT2; CG3812; dAGPAT1; DmAGPAT1/2; Dmel\CG3812
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to several human genes including AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Agpat1 in Genome Data Viewer
    Location:
    11B16-11C1; 1-39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12765266..12772851)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12659299..12666884)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PAICS bifunctional enzyme Neighboring gene pirate Neighboring gene uncharacterized protein Neighboring gene Phosphodiesterase 9 Neighboring gene Neprilysin 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. Tian Y, et al. PLoS Genet, 2011 Apr. PMID 21533227, Free PMC Article
    2. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
    3. Diverse roles of phosphatidate phosphatases in insect development and metabolism. Lehmann M. Insect Biochem Mol Biol, 2021 Jun. PMID 32931938, Free PMC Article
    4. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article
    5. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 12770914-12771560 mobile_element_type = transposon:1360{}115

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-Acylglycerol-3-phosphate O-acyltransferase 1
    Names
    Agpat1-PA
    Agpat1-PB
    Agpat1-PC
    CG3812-PA
    CG3812-PB
    CG3812-PC
    NP_001259494.1
    NP_572828.1
    NP_727641.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12765266..12772851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167337.2 → NP_727641.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYJ4
      Related
      FBpp0073522
      Conserved Domains (1) summary
      cd07989
      Location:70 → 254
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    2. NM_132600.2 → NP_572828.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYJ4
      Related
      FBpp0073521
      Conserved Domains (1) summary
      cd07989
      Location:70 → 254
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    3. NM_001272565.1 → NP_001259494.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYJ4
      Conserved Domains (1) summary
      cd07989
      Location:70 → 254
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYJ4 Q9VYJ4

    Gene LinkOut

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