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    cag cag [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36157, updated on 9-Dec-2024

    Summary

    Official Symbol
    cagprovided by FlyBase
    Official Full Name
    cagprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017414
    Locus tag
    Dmel_CG12346
    See related
    AllianceGenome:FB:FBgn0017414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12346; Dmel\CG12346
    Summary
    Predicted to enable DNA binding activity. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B); TIGD4 (tigger transposable element derived 4); and TIGD6 (tigger transposable element derived 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cag in Genome Data Viewer
    Location:
    47C5-47C6; 2-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10893034..10894414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6780539..6781919, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hydroxyacid oxidase Neighboring gene uncharacterized protein Neighboring gene mir-1008 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14 subunit Neighboring gene RNA polymerase II, I and III subunit E

    Genomic regions, transcripts, and products

    Interactions

    General protein information

    Preferred Names
    cag
    Names
    CG12346-PA
    CG12346-PB
    cag-PA
    cag-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10893034..10894414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057859.4 → NP_477207.1  cag, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91673, Q7JR24
      Related
      FBpp0087334
      Conserved Domains (2) summary
      smart00674
      Location:78 → 141
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:7 → 60
      CENP-B_N; CENP-B N-terminal DNA-binding domain
    2. NM_001273947.1 → NP_001260876.1  cag, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91673, Q7JR24
      Conserved Domains (2) summary
      smart00674
      Location:78 → 141
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:7 → 60
      CENP-B_N; CENP-B N-terminal DNA-binding domain
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