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    Rhbdl1 rhomboid like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhbdl1provided by RGD
    Official Full Name
    rhomboid like 1provided by RGD
    Primary source
    RGD:620699
    See related
    EnsemblRapid:ENSRNOG00000019921 AllianceGenome:RGD:620699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rhbdl
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Orthologous to human RHBDL1 (rhomboid like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 44.0), Adrenal (RPKM 14.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhbdl1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15359027..15362530, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14854514..14858848, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15201503..15205856, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene ras homolog family member T2 Neighboring gene WD repeat domain 90 Neighboring gene MAPK regulated co-repressor interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid. Pascall JC, et al. FEBS Lett, 1998 Jun 16. PMID 9662444
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid-related protein 1
    Names
    RRP
    rhomboid protease 1
    rhomboid, veinlet-like 1
    rhomboid-like protein 1
    NP_001178751.1
    XP_006245956.1
    XP_008765759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191822.1 → NP_001178751.1  rhomboid-related protein 1

      See identical proteins and their annotated locations for NP_001178751.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HD64, G3V8M7
      Related
      ENSRNOP00000026971.5, ENSRNOT00000026971.7
      Conserved Domains (1) summary
      pfam01694
      Location:174 → 328
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15359027..15362530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245894.5 → XP_006245956.1  rhomboid-related protein 1 isoform X2

      UniProtKB/TrEMBL
      G3V8M7
      Conserved Domains (1) summary
      pfam01694
      Location:176 → 330
      Rhomboid; Rhomboid family

    2. XM_008767537.4 → XP_008765759.1  rhomboid-related protein 1 isoform X1

      UniProtKB/TrEMBL
      G3V8M7
      Conserved Domains (1) summary
      pfam01694
      Location:234 → 388
      Rhomboid; Rhomboid family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88779.1 GenPept UniProtKB/Swiss-Prot:O88779

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.