Slc22a1 solute carrier family 22 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a1provided by RGD
Official Full Name: solute carrier family 22 member 1provided by RGD
Primary source: RGD:3224
See related: EnsemblRapid:ENSRNOG00000016337 AllianceGenome:RGD:3224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oct1; Orct1; Roct1
Summary: Enables several functions, including dopamine:sodium symporter activity; identical protein binding activity; and organic cation transmembrane transporter activity. Involved in several processes, including metanephric proximal tubule development; monoamine transport; and monoatomic ion transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 828.7) and Liver (RPKM 684.1) See more
Orthologs: human all
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Genomic context

Location:: 1q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50624339..50651437)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (48076657..48103679)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48273639..48300645)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
Title: Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
The binding and transport of model substrate 1-methyl-4-phenylpyridinium(+) (MPP(+)) by cell-free-expressed fusion proteins of rOCT1.
Title: Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Protein and mRNA expression levels of Oat1, Oat3, Oct1, and Oct2 were significantly decreased in adenine-induced chronic renal failure rats.
Title: Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.
Hnf4alpha occupies Oat1, Oat3, and Oct1 proximal promoters in the in vivo differentiating rat kidney.
Title: Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule.
A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
Title: A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
Title: The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
Findings suggest that Oct-1 as a co-factor might directly or indirectly collaborate in a cell-type-specific manner with the intronic enhancer in the amelogenin gene.
Title: Identification of a suppressor element in the amelogenin promoter.
Five amino acids in the innermost cavity of the substrate binding cleft of Roct1 interact with extracellular and intracellular corticosterone.
Title: Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone.
During endotoxemia NO, produced by iNOS, is responsible for a down-regulation of the renal influx carriers, Oct1 and Oct2.
Title: Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.
Effects of the sulfhydryl reagent methylmethanethiosulfonate (MMTS) on functions of organic cation transporters (OCTs) were investigated.
Title: Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:144418

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:545989

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (R)-carnitine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables (R)-carnitine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetylcholine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dopamine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables norepinephrine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in (R)-carnitine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in (R)-carnitine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in acetylcholine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine transport	ISO Inferred from Sequence Orthology more info
involved_in acyl carnitine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in acyl carnitine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	IEA Inferred from Electronic Annotation more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in quaternary ammonium group transport	IDA Inferred from Direct Assay more info	PubMed
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	ISO Inferred from Sequence Orthology more info
involved_in spermidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 1

Names: organic cation transporter 1; solute carrier family 22 (organic cation transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012697.1 → NP_036829.1 solute carrier family 22 member 1

See identical proteins and their annotated locations for NP_036829.1

Status: PROVISIONAL

Source sequence(s)

X78855

UniProtKB/Swiss-Prot

O35882, Q63089, Q6AYW1

UniProtKB/TrEMBL

A6KJW8

Related

ENSRNOP00000022254.2, ENSRNOT00000022254.7

Conserved Domains (2) summary

cd06174
Location:125 → 515

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 525

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

50624339..50651437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101083.2 → XP_038957011.1 solute carrier family 22 member 1 isoform X1

Related

ENSRNOP00000022068.3, ENSRNOT00000022068.7

Conserved Domains (1) summary

TIGR00898
Location:47 → 399

2A0119; cation transport protein
XM_039101089.2 → XP_038957017.1 solute carrier family 22 member 1 isoform X2

Conserved Domains (1) summary

TIGR00898
Location:5 → 305

2A0119; cation transport protein