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    Myl11 myosin light chain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24584, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Myl11provided by RGD
    Official Full Name
    myosin light chain 11provided by RGD
    Primary source
    RGD:3141
    See related
    EnsemblRapid:ENSRNOG00000017645 AllianceGenome:RGD:3141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MLC2; Myl2; Mylpf; Myolc1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in immune response and skeletal muscle tissue development. Predicted to be part of myosin complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 122880.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myl11 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191257432..191263046)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181829703..181832546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198655835..198658590)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Cd2 (cytoplasmic tail) binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene septin 1 Neighboring gene uncharacterized LOC134483881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The MEF2 site is necessary for induction of the myosin light chain 2 slow promoter in overloaded regenerating plantaris muscle. Leszczynski JK, et al. Life Sci, 2003 Nov 7. PMID 14561531
    2. CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells. Liu X, et al. J Neuroimmunol, 2006 Mar. PMID 16380169
    3. The nucleotide sequence of a rat myosin light chain 2 gene. Nudel U, et al. Nucleic Acids Res, 1984 Sep 25. PMID 6091059, Free PMC Article
    4. Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development. Wang Y, et al. FASEB J, 2007 Jul. PMID 17356007
    5. Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy. Flavigny J, et al. J Mol Med (Berl), 1998 Mar. PMID 9535554

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results demonstrate that the -270MLC2s promoter contains the elements necessary for expression of MLC2s in regenerating overloaded plantaris muscle
      Title: The MEF2 site is necessary for induction of the myosin light chain 2 slow promoter in overloaded regenerating plantaris muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin regulatory light chain 11
    Names
    DTNB
    G2
    MLC-2
    Myosin, light polypeptide 2, alkali
    Myosin, light polypeptide 2, alkali; ventricular, skeletal, slow
    fast skeletal myosin light chain 2
    myosin light chain, phosphorylatable, fast skeletal muscle
    ventricular, skeletal, slow

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012605.2 → NP_036737.1  myosin regulatory light chain 11

      See identical proteins and their annotated locations for NP_036737.1

      Status: VALIDATED

      Source sequence(s)
      BI278596, CB770854, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P04466
      UniProtKB/TrEMBL
      A0A8I6A988, A6I9M4
      Related
      ENSRNOP00000023944.3, ENSRNOT00000023944.8
      Conserved Domains (1) summary
      COG5126
      Location:15 → 154
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191257432..191263046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280787.1 → XP_063136857.1  myosin regulatory light chain 11 isoform X2

      UniProtKB/Swiss-Prot
      P04466
      UniProtKB/TrEMBL
      A6I9M4

    2. XM_039097588.2 → XP_038953516.1  myosin regulatory light chain 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A988
      Conserved Domains (1) summary
      COG5126
      Location:15 → 136
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04466.2 GenPept UniProtKB/Swiss-Prot:P04466

    Gene LinkOut

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