U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Emcn endomucin [ Mus musculus (house mouse) ]

    Gene ID: 59308, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Emcnprovided by MGI
    Official Full Name
    endomucinprovided by MGI
    Primary source
    MGI:MGI:1891716
    See related
    Ensembl:ENSMUSG00000054690 AllianceGenome:MGI:1891716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Muc14; 0610012K22Rik
    Summary
    Predicted to enable carbohydrate binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Is expressed in several structures, including cardiovascular system; early conceptus; hemolymphoid system; lung; and urinary system. Orthologous to human EMCN (endomucin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 46.9), heart adult (RPKM 22.7) and 18 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Emcn in Genome Data Viewer
    Location:
    3 G3; 3 63.65 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137046824..137136830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137341062..137431069)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26107 Neighboring gene STARR-seq mESC enhancer starr_09083 Neighboring gene STARR-seq mESC enhancer starr_09084 Neighboring gene STARR-positive B cell enhancer ABC_E9225 Neighboring gene predicted gene 567 Neighboring gene predicted gene, 38650 Neighboring gene STARR-seq mESC enhancer starr_09085 Neighboring gene predicted gene 4861 Neighboring gene DNA-damage-inducible transcript 4-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration. Engelhard S, et al. Cell Rep, 2024 Jul 23. PMID 38996072
    2. Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Ueno M, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554756
    3. Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. Matsubara A, et al. J Exp Med, 2005 Dec 5. PMID 16314436, Free PMC Article
    4. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Morgan SM, et al. Blood, 1999 Jan 1. PMID 9864158
    5. Non-endothelial expression of endomucin in the mouse and human choroid. Brookins E, et al. Exp Eye Res, 2024 Oct. PMID 39153592,

    See all (298) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-endothelial expression of endomucin in the mouse and human choroid.
      Title: Non-endothelial expression of endomucin in the mouse and human choroid.
    2. Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
      Title: Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
    3. Taken together, it seems likely that endomucin-reactive small blood vessels extended to the podoplanin/E11/gp38-positive odontoblast layers, whereas endomucin-reactive large blood vessels were already present in CD44-immmunopositive sub-odontoblastic layer, indicating the cellular regulation on the vascularization of endomucin-reactive endothelial cells during odontogenesis of the tooth germs.
      Title: Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs.
    4. These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
      Title: Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    endomucin
    Names
    MUC-14
    endomucin-1
    endomucin-1/2
    mucin 14, endothelial
    mucin-14

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163522.1 → NP_001156994.1  endomucin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156994.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA822842, BC003706
      Consensus CDS
      CCDS51075.1
      UniProtKB/Swiss-Prot
      Q78KL2, Q9DCN9, Q9R0H2, Q9ULC1, Q9Z2I1
      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000112603.2, ENSMUST00000122064.8
      Conserved Domains (1) summary
      pfam07010
      Location:1 → 261
      Endomucin; Endomucin

    2. NM_016885.2 → NP_058581.2  endomucin isoform 2 precursor

      See identical proteins and their annotated locations for NP_058581.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA822842, AK002616, BC003706
      Consensus CDS
      CCDS17861.1
      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000114102.2, ENSMUST00000119475.6
      Conserved Domains (1) summary
      pfam07010
      Location:1 → 248
      Endomucin; Endomucin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137046824..137136830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501842.4 → XP_006501905.1  endomucin isoform X1

      See identical proteins and their annotated locations for XP_006501905.1

      UniProtKB/TrEMBL
      A0A0G2JDR2
      Related
      ENSMUSP00000142467.2, ENSMUST00000197511.2
      Conserved Domains (1) summary
      pfam07010
      Location:1 → 223
      Endomucin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0H2.1 GenPept UniProtKB/Swiss-Prot:Q9R0H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools