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    Apbb2 amyloid beta precursor protein binding family B member 2 [ Mus musculus (house mouse) ]

    Gene ID: 11787, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Apbb2provided by MGI
    Official Full Name
    amyloid beta precursor protein binding family B member 2provided by MGI
    Primary source
    MGI:MGI:108405
    See related
    Ensembl:ENSMUSG00000029207 AllianceGenome:MGI:108405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2L; Zfra; Rirl1; FE65L1; 2310007D03Rik
    Summary
    Predicted to enable amyloid-beta binding activity and molecular adaptor activity. Involved in maintenance of lens transparency and smooth muscle contraction. Acts upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.9), cerebellum adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apbb2 in Genome Data Viewer
    Location:
    5 C3.1; 5 34.43 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66456068..66779189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66298725..66619064, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_13303 Neighboring gene STARR-seq mESC enhancer starr_13304 Neighboring gene ubiquitin carboxy-terminal hydrolase L1 Neighboring gene STARR-seq mESC enhancer starr_13305 Neighboring gene LIM and calponin homology domains 1 Neighboring gene STARR-seq mESC enhancer starr_13306 Neighboring gene predicted gene 6517

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an apoptosis inhibitory domain at the C-termini of FE65-like protein. Cao H, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027557
    2. FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing. Suh J, et al. J Neurochem, 2011 Oct. PMID 21824144, Free PMC Article
    3. Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration. Lin YH, et al. Int J Mol Sci, 2022 Nov 22. PMID 36498839, Free PMC Article
    4. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. Suh J, et al. FASEB J, 2015 Jun. PMID 25757569, Free PMC Article
    5. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode. Li H, et al. J Biol Chem, 2008 Oct 3. PMID 18650440

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfra Inhibits the TRAPPC6ADelta-Initiated Pathway of Neurodegeneration.
      Title: Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration.
    2. These data demonstrate a role for FE65 proteins at central and peripheral synapses.
      Title: FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.
    3. Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency.
      Title: FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.
    4. FE65 proteins contribute to physiological APP processing and accumulation of amyloid precursor protein metabolic products resulting from NMDA receptor activation
      Title: FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing.
    5. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode
      Title: Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.
    6. Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly.
      Title: Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
    7. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF
      Title: The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor.
    8. While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.
      Title: Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of lens transparency IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor protein binding family B member 2
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 2
    protein Fe65-like 1
    zinc finger-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201413.2 → NP_001188342.1  amyloid beta precursor protein binding family B member 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57345.1
      UniProtKB/TrEMBL
      Q3TIZ5, Q3U674
      Related
      ENSMUSP00000123978.3, ENSMUST00000160870.8
      Conserved Domains (3) summary
      cd01271
      Location:582 → 708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 553
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    2. NM_001201414.2 → NP_001188343.1  amyloid beta precursor protein binding family B member 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57346.1
      UniProtKB/TrEMBL
      E9PWH3, Q3U674
      Related
      ENSMUSP00000124807.2, ENSMUST00000159512.8
      Conserved Domains (3) summary
      cd01271
      Location:562 → 688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    3. NM_001201415.2 → NP_001188344.1  amyloid beta precursor protein binding family B member 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57344.1
      UniProtKB/TrEMBL
      Q3U674
      Related
      ENSMUSP00000125211.3, ENSMUST00000159786.8
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    4. NM_001201416.1 → NP_001188345.1  amyloid beta precursor protein binding family B member 2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple coding exons from the 5' end and has an alternate 5' exon compared to variant 1. It initiates translation at a downstream start codon. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC131752
      UniProtKB/TrEMBL
      Q3T9N0
      Related
      ENSMUST00000162955.8
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    5. NM_001310626.2 → NP_001297555.1  amyloid beta precursor protein binding family B member 2 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS80292.1
      UniProtKB/TrEMBL
      Q3TDW6, Q3U674
      Related
      ENSMUSP00000125116.2, ENSMUST00000162366.8
      Conserved Domains (3) summary
      cd01271
      Location:560 → 686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    6. NM_009686.3 → NP_033816.1  amyloid beta precursor protein binding family B member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS51510.1
      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Related
      ENSMUSP00000123752.3, ENSMUST00000162349.8
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      66456068..66779189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503696.5 → XP_006503759.1  amyloid beta precursor protein binding family B member 2 isoform X13

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    2. XM_006503697.5 → XP_006503760.1  amyloid beta precursor protein binding family B member 2 isoform X13

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    3. XM_036164748.1 → XP_036020641.1  amyloid beta precursor protein binding family B member 2 isoform X9

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    4. XM_030254081.2 → XP_030109941.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563 → 689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    5. XM_030254078.2 → XP_030109938.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    6. XM_006503691.5 → XP_006503754.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    7. XM_030254079.2 → XP_030109939.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    8. XM_006503690.5 → XP_006503753.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    9. XM_030254080.2 → XP_030109940.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563 → 689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    10. XM_030254082.2 → XP_030109942.1  amyloid beta precursor protein binding family B member 2 isoform X10

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    11. XM_006503694.5 → XP_006503757.1  amyloid beta precursor protein binding family B member 2 isoform X8

      UniProtKB/TrEMBL
      E9PWH3, Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:562 → 688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    12. XM_006503693.5 → XP_006503756.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:564 → 690
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 535
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    13. XM_006503692.5 → XP_006503755.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:582 → 708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    14. XM_017320620.3 → XP_017176109.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:583 → 709
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    15. XM_011240693.4 → XP_011238995.1  amyloid beta precursor protein binding family B member 2 isoform X3

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    16. XM_006503688.5 → XP_006503751.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    17. XM_036164747.1 → XP_036020640.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563 → 689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    18. XM_036164746.1 → XP_036020639.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    19. XM_017320622.3 → XP_017176111.1  amyloid beta precursor protein binding family B member 2 isoform X12

      Conserved Domains (3) summary
      cd01271
      Location:311 → 437
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:143 → 282
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:19 → 47
      WW; WW domain

    20. XM_036164749.1 → XP_036020642.1  amyloid beta precursor protein binding family B member 2 isoform X11

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain
      cl17171
      Location:585 → 647
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBR4.2 GenPept UniProtKB/Swiss-Prot:Q9DBR4

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