Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj2provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 2provided by RGD
Primary source: RGD:61968
See related: EnsemblRapid:ENSRNOG00000064933 AllianceGenome:RGD:61968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kir2.1
Summary: Predicted to enable identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and voltage-gated potassium channel activity. Involved in cellular response to mechanical stimulus; positive regulation of potassium ion transmembrane transport; and regulation of cardiac muscle cell contraction. Located in several cellular components, including T-tubule; dendritic spine; and intercalated disc. Is active in glutamatergic synapse and postsynaptic membrane. Used to study myocardial infarction. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 102.9), Heart (RPKM 96.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (96560225..96570788)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (96060834..96071397)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (99429337..99442520)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration.
Title: Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration.
Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway.
Title: Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway.
Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel.
Title: Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel.
Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation.
Title: Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation.
Altering integrin engagement regulates membrane localization of Kir2.1 channels.
Title: Altering integrin engagement regulates membrane localization of K(ir)2.1 channels.
The NaV1.5-Kir2.1 macromolecular complex pre-assembles early in the forward trafficking pathway. Therefore, disruption of Kir2.1 trafficking in cardiomyocytes affects trafficking of NaV1.5, which may have important implications in the mechanisms of arrhythmias in inheritable cardiac diseases.
Title: Cardiac Kir2.1 and Na(V)1.5 Channels Traffic Together to the Sarcolemma to Control Excitability.
Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Title: Role of plasma membrane-associated AKAPs for the regulation of cardiac I(K1) current by protein kinase A.
Moreover, the in vivo study showed that rat-VSMC switched to proliferative phenotypes and that knockdown of Kir2.1 significantly inhibited neointimal formation after rat carotid injury. Kir2.1 may be a potential therapeutic target in the treatment of cardiovascular diseases, such as atherosclerosis and restenosis following percutaneous coronary intervention.
Title: Kir2.1 regulates rat smooth muscle cell proliferation, migration, and post-injury carotid neointimal formation.
Nav1.5 N-terminal domain binding to alpha1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
Title: Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels.
Th1 response regulates Kir2.1 expression in infarcted hearts and valsartan regulates Th1 response to improve cardiac ion channel remodeling following myocardial infarction.
Title: Valsartan Attenuates KIR2.1 by Downregulating the Th1 Immune Response in Rats Following Myocardial Infarction.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnj2 (e-PCR), detects polymorphism
- UniSTS:143659

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within magnesium ion transport	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of skeletal muscle contraction via regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in relaxation of skeletal muscle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inward rectifier potassium channel 2

Names: IRK-1; RBL-IRK1; inward rectifier K(+) channel Kir2.1; potassium channel, inwardly rectifying subfamily J member 2; potassium voltage-gated channel subfamily J member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017296.2 → NP_058992.1 inward rectifier potassium channel 2

See identical proteins and their annotated locations for NP_058992.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q64273

UniProtKB/TrEMBL

A6HKE4

Related

ENSRNOP00000079758.1, ENSRNOT00000102334.2

Conserved Domains (3) summary

pfam01007
Location:48 → 186

IRK; Inward rectifier potassium channel

pfam08466
Location:1 → 47

IRK_N; Inward rectifier potassium channel N-terminal

pfam17655
Location:193 → 366

IRK_C; Inward rectifier potassium channel C-terminal domain