Casp6 caspase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Casp6provided by RGD
Full Name: caspase 6provided by RGD
Primary source: RGD:70967
See related: EnsemblRapid:ENSRNOG00000052613 AllianceGenome:RGD:70967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mch2
Summary: Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in axon and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (221140287..221152727)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (218466063..218478503)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (235341326..235353715)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Title: Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
To evaluate an axon autonomous role of Casp6, study examined axon integrity following transection ex vivo, and analyzed the serial morphological fragmentation of neurofilament expression as a structural index of axonal degeneration. Adding a specific Casp6 inhibitor to the preparation delayed neurofilament fragmentation.
Title: Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration.
Caspase-6 shows a time-dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat.
Title: [A study on the time-dependent expression of caspase-6 during repair of skin contusion in rats].
Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells
Title: Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells.
Neuronal caspase-6 immunoreactivity was markedly upregulated within cortex and hippocampus in relation to bursts of polyspike paroxysmal discharges.
Title: Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
nuclear fragmentation in rat blastocysts is apparently mediated by the activation of caspase-6
Title: Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose.
Testosterone inhibits apoptosis in the ventral prostate by potentially targeting the transcriptional activity of effector caspase-6 genes (but not of casapase-8 gene) as well as the cleavage of procaspase-6 into active enzymes.
Title: Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in acute inflammatory response to non-antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to staurosporine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to staurosporine	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to iron ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-6

Names: CASP-6; apoptotic protease Mch-2

NP_001258913.1

EC 3.4.22.59

NP_113963.2

EC 3.4.22.59

XP_017446624.1

EC 3.4.22.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271984.1 → NP_001258913.1 caspase-6

See identical proteins and their annotated locations for NP_001258913.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC078785, DY310578, FM068086

UniProtKB/Swiss-Prot

O35397

UniProtKB/TrEMBL

Q6AZ23

Conserved Domains (1) summary

smart00115
Location:20 → 273

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_031775.3 → NP_113963.2 caspase-6

See identical proteins and their annotated locations for NP_113963.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC078785, FM068086

UniProtKB/Swiss-Prot

O35397

UniProtKB/TrEMBL

Q6AZ23

Conserved Domains (1) summary

smart00115
Location:20 → 273

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

221140287..221152727

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591135.2 → XP_017446624.1 caspase-6 isoform X1

UniProtKB/Swiss-Prot

O35397

UniProtKB/TrEMBL

F6Q5I5

Related

ENSRNOP00000013049.4, ENSRNOT00000013049.8

Conserved Domains (1) summary

smart00115
Location:19 → 272

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues