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    Scgb2a1 secretoglobin, family 2A, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361725, updated on 9-Dec-2024

    Summary

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    Symbol
    Scgb2a1provided by RGD
    Full Name
    secretoglobin, family 2A, member 1provided by RGD
    Primary source
    RGD:735031
    See related
    EnsemblRapid:ENSRNOG00000023151 AllianceGenome:RGD:735031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C3.1; Psbp1; Psbpc3; Scgb2a2
    Summary
    Predicted to enable steroid binding activity. Predicted to be involved in androgen receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SCGB2A1 (secretoglobin family 2A member 1) and SCGB2A2 (secretoglobin family 2A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 6.9), Brain (RPKM 3.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scgb2a1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215922751..215926114)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206497848..206501211)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225899313..225902676)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein, pseudogene 1 Neighboring gene secretoglobin, family 1D, member 2, pseudogene 1 Neighboring gene inner centromere protein Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural studies on rat prostatic binding protein. The primary structure of its glycosylated component C3. Peeters B, et al. Eur J Biochem, 1981 Mar 16. PMID 7014218
    2. Response elements of the androgen-regulated C3 gene. Tan J, et al. J Biol Chem, 1992 Apr 15. PMID 1339454
    3. Response elements of the androgen-regulated C3 gene. Tan JA, et al. J Biol Chem, 1992 Mar 5. PMID 1537831
    4. Sequence-specific binding of androgen-receptor complexes to prostatic binding protein genes. Claessens F, et al. Mol Cell Endocrinol, 1990 Dec 21. PMID 2095354
    5. Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. Allison J, et al. Mol Cell Biol, 1989 May. PMID 2747651, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72333

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretoglobin family 2A member 2
    Names
    androgen receptor DNA-binding domain DNA
    prostatein C3 subunit
    prostatein peptide C3
    prostatic steroid-binding protein 1
    prostatic steroid-binding protein C3
    prostatic steroid-binding protein C3.2
    secretoglobin, family 2A, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203333.2 → NP_976078.1  secretoglobin family 2A member 2 precursor

      See identical proteins and their annotated locations for NP_976078.1

      Status: VALIDATED

      Source sequence(s)
      BC062401, CB791758, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P02780, Q63463, Q9JHB9
      UniProtKB/TrEMBL
      A6HZZ8
      Related
      ENSRNOP00000037869.2, ENSRNOT00000031612.5
      Conserved Domains (1) summary
      pfam01099
      Location:1 → 91
      Uteroglobin; Uteroglobin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215922751..215926114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080770.3: Suppressed sequence

      Description
      NM_080770.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02780.1 GenPept UniProtKB/Swiss-Prot:P02780
    Q9JHB9.1 GenPept UniProtKB/Swiss-Prot:Q9JHB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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