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    YEA4 Yea4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YEA4
    Official Full Name
    Yea4p
    Primary source
    SGD:S000000730
    Locus tag
    YEL004W
    See related
    AllianceGenome:SGD:S000000730; FungiDB:YEL004W; VEuPathDB:YEL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables UDP-N-acetylglucosamine transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport; UDP-glucose transmembrane transport; and chitin biosynthetic process. Located in endoplasmic reticulum. Orthologous to human SLC35B4 (solute carrier family 35 member B4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YEA4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (146951..147979)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene NAD+ transporter Neighboring gene Vab2p Neighboring gene tubulin-binding prefolding complex subunit GIM4 Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Yeast Yea4p, a uridine diphosphate-N-acetylglucosamine transporter localized in the endoplasmic reticulum and required for chitin synthesis. Roy SK, et al. J Biol Chem, 2000 May 5. PMID 10788474
    2. Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Esther CR Jr, et al. Biochemistry, 2008 Sep 2. PMID 18693752, Free PMC Article
    3. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article
    4. Cross-linking Mass Spectrometry Analysis of the Yeast Nucleus Reveals Extensive Protein-Protein Interactions Not Detected by Systematic Two-Hybrid or Affinity Purification-Mass Spectrometry. Bartolec TK, et al. Anal Chem, 2020 Jan 21. PMID 31851481
    5. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UDP-xylose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-glucose transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in UDP-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-xylose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yea4p
    NP_010912.1
    • Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      146951..147979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178819.1 → NP_010912.1  TPA: Yea4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLP3, P40004
      UniProtKB/TrEMBL
      A6ZQU3, B3LS08, C7GKH5, C8Z6Z5, G2WCM7, N1P5E4
      Conserved Domains (1) summary
      pfam08449
      Location:3 → 327
      UAA; UAA transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40004.1

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