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    Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 18816, updated on 4-Jan-2025

    Summary

    Official Symbol
    Serpinf2provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade F, member 2provided by MGI
    Primary source
    MGI:MGI:107173
    See related
    Ensembl:ENSMUSG00000038224 AllianceGenome:MGI:107173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pli; Serpimf2
    Summary
    Predicted to enable protease binding activity; protein homodimerization activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including collagen fibril organization; maintenance of blood vessel diameter homeostasis by renin-angiotensin; and positive regulation of biosynthetic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; pancreas epithelium; urinary system; and yolk sac. Used to study alpha-2-plasmin inhibitor deficiency. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in liver adult (RPKM 505.8), liver E18 (RPKM 427.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Serpinf2 in Genome Data Viewer
    Location:
    11 B5; 11 45.89 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75322562..75330327, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75431736..75439501, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35337 Neighboring gene predicted gene 12337 Neighboring gene predicted gene, 35391 Neighboring gene WD repeat domain 81 Neighboring gene STARR-positive B cell enhancer ABC_E3973 Neighboring gene STARR-positive B cell enhancer ABC_E10687 Neighboring gene STARR-seq mESC enhancer starr_29995 Neighboring gene Mir22 host gene (non-protein coding) Neighboring gene microRNA 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity  
    enables protease binding  
    enables protease binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity  
    Process Evidence Code Pubs
    involved_in acute-phase response  
    involved_in blood vessel morphogenesis PubMed 
    involved_in collagen fibril organization PubMed 
    involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin PubMed 
    involved_in negative regulation of endopeptidase activity  
    involved_in negative regulation of fibrinolysis  
    involved_in negative regulation of fibrinolysis  
    involved_in negative regulation of plasminogen activation  
    involved_in negative regulation of plasminogen activation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of cell differentiation PubMed 
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta production PubMed 
    involved_in positive regulation of transforming growth factor beta production  
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    part_of fibrinogen complex  
    part_of fibrinogen complex  

    General protein information

    Preferred Names
    alpha-2-antiplasmin
    Names
    alpha-2-AP
    alpha-2-PI
    alpha-2-plasmin inhibitor
    pigment epithelium derived factor
    plasmin inhibitor alpha 2
    serine (or cysteine) proteinase inhibitor, clade F, member 2
    serpin F2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008878.2NP_032904.1  alpha-2-antiplasmin precursor

      See identical proteins and their annotated locations for NP_032904.1

      Status: VALIDATED

      Source sequence(s)
      AA269351, AK077563, AL591496, GQ896353
      Consensus CDS
      CCDS25046.1
      UniProtKB/Swiss-Prot
      Q61247
      UniProtKB/TrEMBL
      Q5ND36
      Related
      ENSMUSP00000048704.3, ENSMUST00000043696.9
      Conserved Domains (1) summary
      cd02053
      Location:82433
      alpha2AP; Alpha2-antiplasmin (alpha2AP) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-Antiplasmin forms an inactive 1 : 1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75322562..75330327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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