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    RAD7 UV-damaged DNA-binding protein RAD7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RAD7
    Official Full Name
    UV-damaged DNA-binding protein RAD7
    Primary source
    SGD:S000003813
    Locus tag
    YJR052W
    See related
    AllianceGenome:SGD:S000003813; FungiDB:YJR052W; VEuPathDB:YJR052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ATP-dependent activity, acting on DNA; damaged DNA binding activity; and ubiquitin-protein transferase activity. Involved in nucleotide-excision repair, DNA damage recognition; protein localization; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex and nucleotide-excision repair factor 4 complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RAD7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (532062..533759)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene fumarate reductase Neighboring gene tRNA-Gly Neighboring gene Bfa1p Neighboring gene Kch1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae RAD7 and RAD16 genes are required for inducible excision of endonuclease III sensitive-sites, yet are not needed for the repair of these lesions following a single UV dose. Scott AD, et al. Mutat Res, 1997 Jan 31. PMID 9042418
    2. RAD7 gene of Saccharomyces cerevisiae: transcripts, nucleotide sequence analysis, and functional relationship between the RAD7 and RAD23 gene products. Perozzi G, et al. Mol Cell Biol, 1986 May. PMID 3023893, Free PMC Article
    3. RNA polymerase II transcription suppresses nucleosomal modulation of UV-induced (6-4) photoproduct and cyclobutane pyrimidine dimer repair in yeast. Tijsterman M, et al. Mol Cell Biol, 1999 Jan. PMID 9858617, Free PMC Article
    4. Yeast Rad7-Rad16 complex, specific for the nucleotide excision repair of the nontranscribed DNA strand, is an ATP-dependent DNA damage sensor. Guzder SN, et al. J Biol Chem, 1997 Aug 29. PMID 9268290
    5. The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition. Guzder SN, et al. J Biol Chem, 1998 Mar 13. PMID 9497356

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair, DNA damage recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA damage recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-excision repair factor 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UV-damaged DNA-binding protein RAD7
    NP_012586.1
    • Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      532062..533759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181710.1 → NP_012586.1  TPA: UV-damaged DNA-binding protein RAD7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWM3, P06779
      UniProtKB/TrEMBL
      A6ZQ11, B3LQE1, B5VLK7, C7GVF4, D3UF99, G2WH57, N1P033
      Conserved Domains (2) summary
      cd09293
      Location:228 → 440
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:236 → 261
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06779.3

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