Sik1 salt inducible kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sik1provided by MGI
Official Full Name: salt inducible kinase 1provided by MGI
Primary source: MGI:MGI:104754
See related: Ensembl:ENSMUSG00000024042 AllianceGenome:MGI:104754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msk; Sik; Sik-1; Hrt-20; Snf1lk
Summary: Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of primary metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 31.0), spleen adult (RPKM 26.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.25 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32063222..32074808, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31844248..31855804, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.
Title: Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.
An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice.
Title: An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice.
Long noncoding RNA SNHG1 protects brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-298 and upregulating SIK1 expression.
Title: Long noncoding RNA SNHG1 protects brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-298 and upregulating SIK1 expression.
Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Title: Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway.
Title: Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway.
Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
Title: Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Title: Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Title: Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Title: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1).
Title: Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1).

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237617

Snf1lk (e-PCR), detects polymorphism
- UniSTS:259145

RH134693 (e-PCR)
- UniSTS:217972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase SIK1

Names: Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); SNF1-like kinase; myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK

NP_034961.2

EC 2.7.11.1

XP_036016256.1

EC 2.7.11.1

XP_036016257.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010831.3 → NP_034961.2 serine/threonine-protein kinase SIK1

See identical proteins and their annotated locations for NP_034961.2

Status: VALIDATED

Source sequence(s)

AC166654, AK141817

Consensus CDS

CCDS37552.1

UniProtKB/Swiss-Prot

Q3UR46, Q60670

UniProtKB/TrEMBL

Q571I6

Related

ENSMUSP00000024839.5, ENSMUST00000024839.6

Conserved Domains (3) summary

smart00220
Location:27 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14408
Location:300 → 349

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cd14071
Location:26 → 278

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32063222..32074808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160364.1 → XP_036016257.1 serine/threonine-protein kinase SIK1 isoform X2

UniProtKB/TrEMBL

Q571I6

Conserved Domains (2) summary

cd14408
Location:208 → 257

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cl21453
Location:1 → 186

PKc_like; Protein Kinases, catalytic domain
XM_036160363.1 → XP_036016256.1 serine/threonine-protein kinase SIK1 isoform X1

UniProtKB/TrEMBL

Q571I6

Conserved Domains (2) summary

cd14408
Location:223 → 272

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cl21453
Location:1 → 201

PKc_like; Protein Kinases, catalytic domain