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    ICU2 DNA-directed DNA polymerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836845, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ICU2
    Official Full Name
    DNA-directed DNA polymerase
    Primary source
    TAIR:AT5G67100
    Locus tag
    AT5G67100
    See related
    Araport:AT5G67100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    INCURVATA2; K21H1.14; K21H1_14
    Summary
    Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering.
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    Genomic context

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    See ICU2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    31
    Sequence:
    Chromosome: 5; NC_003076.8 (26776953..26786431)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ralf-like 34 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene PLC-like phosphodiesterases superfamily protein Neighboring gene F-box/RNI-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis INCURVATA2 Regulates Salicylic Acid and Abscisic Acid Signaling, and Oxidative Stress Responses. Micol-Ponce R, et al. Plant Cell Physiol, 2015 Nov. PMID 26423959
    2. Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis. Derboven E, et al. PLoS Genet, 2014 Oct. PMID 25299252, Free PMC Article
    3. Mutation in the catalytic subunit of DNA polymerase alpha influences transcriptional gene silencing and homologous recombination in Arabidopsis. Liu J, et al. Plant J, 2010 Jan. PMID 19769574
    4. The catalytic subunit of Arabidopsis DNA polymerase α ensures stable maintenance of histone modification. Hyun Y, et al. Development, 2013 Jan 1. PMID 23154417
    5. Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis. Serrano-Cartagena J, et al. Genetics, 2000 Nov. PMID 11063708, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results uncover a role for ICU2 in the regulation of genes involved in abscisic acid signaling as well as in salicylic acid biosynthesis and accumulation.
      Title: Arabidopsis INCURVATA2 Regulates Salicylic Acid and Abscisic Acid Signaling, and Oxidative Stress Responses.
    2. Dna polymerase alpha plays a genome-wide role in DNA replication and telomere stability.
      Title: Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.
    3. ICU2 facilitates histone assembly in dividing cells, demonstrating a possible mechanism for ICU2-mediated epigenetic maintenance.
      Title: The catalytic subunit of Arabidopsis DNA polymerase α ensures stable maintenance of histone modification.
    4. Results suggest that DNA polymerase alpha is involved in mediating epigenetic states and in DNA homologous recombination in Arabidopsis.
      Title: Mutation in the catalytic subunit of DNA polymerase alpha influences transcriptional gene silencing and homologous recombination in Arabidopsis.
    5. The positional cloning and characterization of INCURVATA2 (ICU2), which encodes the putative catalytic subunit of the DNA polymerase alpha of Arabidopsis thaliana.
      Title: INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126110.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of flower development NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed DNA polymerase
    NP_201511.2
    • INCURVATA2 (ICU2); FUNCTIONS IN: DNA-directed DNA polymerase activity; INVOLVED IN: negative regulation of flower development, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Zinc finger, DNA-directed DNA polymerase, family B, alpha (InterPro:IPR015088), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (TAIR:AT5G63960.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26776953..26786431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345811.1 → NP_001331725.1  DNA-directed DNA polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K285, Q9FHA3
      UniProtKB/TrEMBL
      A0A178UHA5, A0A5S9YIV3, A0A7G2FL28
      Conserved Domains (2) summary
      TIGR00592
      Location:53 → 1275
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1318 → 1522
      zf-DNA_Pol; DNA Polymerase alpha zinc finger

    2. NM_126110.3 → NP_201511.2  DNA-directed DNA polymerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K285, Q9FHA3
      UniProtKB/TrEMBL
      A0A178UHA5, A0A5S9YIV3, A0A7G2FL28
      Conserved Domains (2) summary
      TIGR00592
      Location:53 → 1275
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:1318 → 1522
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FHA3.2

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