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    IES4 Ies4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854361, updated on 17-Dec-2024

    Summary

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    Official Symbol
    IES4
    Official Full Name
    Ies4p
    Primary source
    SGD:S000005715
    Locus tag
    YOR189W
    See related
    AllianceGenome:SGD:S000005715; FungiDB:YOR189W; VEuPathDB:YOR189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA damage response and telomere maintenance via recombination. Located in nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IES4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (689624..689974)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene translation elongation factor Tu Neighboring gene Msb1p Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene translocase ULS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Kapoor P, et al. Mol Cell, 2015 Jun 4. PMID 25959398, Free PMC Article
    2. The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation. Yao W, et al. Mol Cell Biol, 2016 Jan 11. PMID 26755556, Free PMC Article
    3. Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates. Hauer MH, et al. Nat Struct Mol Biol, 2017 Feb. PMID 28067915
    4. Identification of Topological Network Modules in Perturbed Protein Interaction Networks. Sardiu ME, et al. Sci Rep, 2017 Mar 8. PMID 28272416, Free PMC Article
    5. Structure and functional interactions of INO80 actin/Arp module. Zhang X, et al. J Mol Cell Biol, 2019 May 1. PMID 30388237, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ies4 subunit of the INO80 complex is a functional component in the Mec1/Tel1 DNA damage signaling pathway that modulates checkpoint responses.
      Title: Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ies4p
    NP_014832.1
    • Component of the INO80 chromatin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      689624..689974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183608.1 → NP_014832.1  TPA: Ies4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2P5, Q08561
      UniProtKB/TrEMBL
      A6ZP34, B3LJL9, C7GLQ5, C8ZGU9, G2WN62, N1NVU6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08561.1

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