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    APS1 Aps1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APS1
    Official Full Name
    Aps1p
    Primary source
    SGD:S000004160
    Locus tag
    YLR170C
    See related
    AllianceGenome:SGD:S000004160; FungiDB:YLR170C; VEuPathDB:YLR170C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAP19
    Summary
    Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (500579..501049, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ubiquitin-ribosomal 40S subunit protein S31 fusion protein Neighboring gene Ups2p Neighboring gene diphthine synthase Neighboring gene Tag1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins. Nakai M, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 8373805
    2. The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. Phan HL, et al. EMBO J, 1994 Apr 1. PMID 8157009, Free PMC Article
    3. Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. Phelan JP, et al. J Cell Sci, 2006 Oct 15. PMID 17003107
    4. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339
    5. P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes. Liu K, et al. Mol Biol Cell, 2008 Aug. PMID 18508916, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drs2p acts independently of coat recruitment to facilitate AP-1/clathrin-coated vesicle budding from the TGN
      Title: P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aps1p
    NP_013271.1
    • Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      500579..501049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182057.1 → NP_013271.1  TPA: Aps1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYH5, P35181
      UniProtKB/TrEMBL
      A7A162, B3RH64, B5VN89, C7GIW1, C8ZDE3, G2WJ04
      Conserved Domains (1) summary
      cd14831
      Location:5 → 149
      AP1_sigma; AP-1 complex subunit sigma
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35181.1

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