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    PTM1 Ptm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTM1
    Official Full Name
    Ptm1p
    Primary source
    SGD:S000001522
    Locus tag
    YKL039W
    See related
    AllianceGenome:SGD:S000001522; FungiDB:YKL039W; VEuPathDB:YKL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane; cytosol; and early endosome membrane. Predicted to be active in Golgi apparatus and membrane. Orthologous to human TMEM87A (transmembrane protein 87A) and TMEM87B (transmembrane protein 87B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTM1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (362622..364193)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ESCRT-III subunit protein VPS24 Neighboring gene Nfu1p Neighboring gene ncRNA Neighboring gene Rgt1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis. Yap WS, et al. J Cell Sci, 2020 Nov 5. PMID 33033181, Free PMC Article
    2. Two novel effectors of trafficking and maturation of the yeast plasma membrane H(+) -ATPase. Geva Y, et al. Traffic, 2017 Oct. PMID 28727280, Free PMC Article
    3. The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast. Yu H, et al. Elife, 2022 Apr 11. PMID 35404228, Free PMC Article
    4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
    5. Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress. Bertgen L, et al. Cell Rep, 2024 Apr 23. PMID 38551959

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ptm1p
    NP_012885.2
    • hypothetical protein; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      362622..364193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179605.1 → NP_012885.2  TPA: Ptm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012885.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZS6, D6VXP7, P32857
      UniProtKB/TrEMBL
      B5VMB7, C7GP34, C8ZCD1, N1P2F2
      Conserved Domains (1) summary
      pfam06814
      Location:157 → 447
      Lung_7-TM_R; Lung seven transmembrane receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32857.2

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