U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FLO11 Flo11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854836, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FLO11
    Official Full Name
    Flo11p
    Primary source
    SGD:S000001458
    Locus tag
    YIR019C
    See related
    AllianceGenome:SGD:S000001458; FungiDB:YIR019C; VEuPathDB:YIR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MUC1; STA4
    Summary
    Involved in several processes, including invasive growth in response to glucose limitation; pseudohyphal growth; and single-species biofilm formation. Located in cellular bud neck; extracellular region; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FLO11 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (389572..393675, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Yap5p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The N-terminal domain of the Flo11 protein from Saccharomyces cerevisiae is an adhesin without mannose-binding activity. Goossens KV, et al. FEMS Yeast Res, 2012 Feb. PMID 22129043
    2. Controlled expression of the dominant flocculation genes FLO1, FLO5, and FLO11 in Saccharomyces cerevisiae. Govender P, et al. Appl Environ Microbiol, 2008 Oct. PMID 18708514, Free PMC Article
    3. Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Fidalgo M, et al. Yeast, 2008 Dec. PMID 19160455
    4. FLO11 gene length and transcriptional level affect biofilm-forming ability of wild flor strains of Saccharomyces cerevisiae. Zara G, et al. Microbiology (Reading), 2009 Dec. PMID 19729408
    5. Epigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population-level heterogeneity in its expression. Octavio LM, et al. PLoS Genet, 2009 Oct. PMID 19798446, Free PMC Article

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
      Title: Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
    2. The dual role of amyloid-beta-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
      Title: The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
    3. Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
      Title: Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
    4. Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
      Title: Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
    5. Study provides clear evidence of the functions of the Tup1p and Cyc8p regulators in biofilm colony formation. Cyc8p itself is a repressor of FLO11 gene expression and of the formation of the structured architecture of colony biofilms, whereas Tup1p counteracts Cyc8p, being a positive regulator of FLO11 expression and colony complexity.
      Title: Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.
    6. by deleting many of the known transcriptional activators of invasion, as well as the gene encoding the cell surface protein Flo11 from five relevant segregants and showing that these individuals differ in the genes they require for invasion
      Title: Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity.
    7. IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait.We also show that this ability to disrupt FLO11 repression is not unique to IRA2
      Title: Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions.
    8. Interactions by the fungal Flo11 adhesin depend on a fibronectin type III-like adhesin domain girdled by aromatic bands.
      Title: Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands.
    9. Gcn5 plays an important role in the regulatory network of FLO11 expression via Gcn4 by downregulating ICR1 expression, which derepresses FLO11 for promoting pseudohyphal development
      Title: The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae.
    10. Flo11 downregulation causes filamentous and invasive growth of rho mutants.
      Title: Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion involved in single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in filamentous growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flocculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single-species surface biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Flo11p
    NP_012284.3
    • GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      389572..393675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179541.3 → NP_012284.3  TPA: Flo11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012284.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVV0, P08068, P08640
      UniProtKB/TrEMBL
      A0A8H4BZA4, Q6LCS8
      Conserved Domains (2) summary
      pfam05109
      Location:1071 → 1322
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam10182
      Location:43 → 193
      Flo11; Flo11 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08640.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools