U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRE1 proteasome core particle subunit beta 4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856731, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PRE1
    Official Full Name
    proteasome core particle subunit beta 4
    Primary source
    SGD:S000000814
    Locus tag
    YER012W
    See related
    AllianceGenome:SGD:S000000814; FungiDB:YER012W; VEuPathDB:YER012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PRE1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (177835..178431)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GPI-anchored mannoprotein Neighboring gene tRNA-Glu Neighboring gene DEAH-box ATP-dependent RNA helicase PRP22 Neighboring gene oxygen-dependent protoporphyrinogen oxidase Neighboring gene Bud25p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. Heinemeyer W, et al. EMBO J, 1991 Mar. PMID 2001673, Free PMC Article
    2. The proteasome/multicatalytic-multifunctional proteinase. In vivo function in the ubiquitin-dependent N-end rule pathway of protein degradation in eukaryotes. Richter-Ruoff B, et al. FEBS Lett, 1992 May 11. PMID 1321727
    3. The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis. Hilt W, et al. J Biol Chem, 1993 Feb 15. PMID 8381431
    4. PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins. Heinemeyer W, et al. J Biol Chem, 1993 Mar 5. PMID 8383129
    5. Characterization of the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. Medintz I, et al. J Bacteriol, 1996 Apr. PMID 8636025, Free PMC Article

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopeptidase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proteasome core particle subunit beta 4
    NP_010928.1
    • Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      177835..178431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178903.1 → NP_010928.1  TPA: proteasome core particle subunit beta 4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLQ9, P22141
      UniProtKB/TrEMBL
      A6ZQV9, B3LS24, B5VHE3, C7GKJ0, C8Z712, G2WCP3, N1PA82
      Conserved Domains (1) summary
      cd03758
      Location:1 → 194
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22141.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.