GDH2 glutamate dehydrogenase (NAD(+)) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GDH2
Official Full Name: glutamate dehydrogenase (NAD(+))
Primary source: SGD:S000002374
Locus tag: YDL215C
See related: AllianceGenome:SGD:S000002374; FungiDB:YDL215C; VEuPathDB:YDL215C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Located in mitochondrion. Is active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GDH2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (70640..73918, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutamate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glutamate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate dehydrogenase (NAD(+))

NP_010066.1

EC 1.4.1.2

NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

70640..73918 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180275.1 → NP_010066.1 TPA: glutamate dehydrogenase (NAD(+)) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010066.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRD9, P33327

UniProtKB/TrEMBL

G2WBV2, N1P679

Conserved Domains (1) summary

cl29306
Location:1 → 1092

Bac_GDH; Bacterial NAD-glutamate dehydrogenase