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    CAR1 arginase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAR1
    Official Full Name
    arginase
    Primary source
    SGD:S000006032
    Locus tag
    YPL111W
    See related
    AllianceGenome:SGD:S000006032; FungiDB:YPL111W; VEuPathDB:YPL111W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPH15
    Summary
    Enables arginase activity; ornithine carbamoyltransferase inhibitor activity; and transition metal ion binding activity. Involved in arginine catabolic process to ornithine and regulation of ornithine metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (339944..340945)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pex25p Neighboring gene tRNA-Met Neighboring gene glycerophosphocholine phosphodiesterase Neighboring gene Cqd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular events associated with induction of arginase in Saccharomyces cerevisiae. Bossinger J, et al. J Bacteriol, 1977 Jul. PMID 326758, Free PMC Article
    2. Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) promoter in response to multiple environmental signals. Smart WC, et al. Mol Cell Biol, 1996 Oct. PMID 8816501, Free PMC Article
    3. Disruption of the CAR1 gene encoding arginase enhances freeze tolerance of the commercial baker's yeast Saccharomyces cerevisiae. Shima J, et al. Appl Environ Microbiol, 2003 Jan. PMID 12514069, Free PMC Article
    4. Isolation of the CAR1 gene from Saccharomyces cerevisiae and analysis of its expression. Sumrada RA, et al. Mol Cell Biol, 1982 Dec. PMID 14582193, Free PMC Article
    5. Antisense-mediated inhibition of arginase (CAR1) gene expression in Saccharomyces cerevisiae. Park H, et al. J Biosci Bioeng, 2001. PMID 16233134

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables arginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ornithine carbamoyltransferase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ornithine carbamoyltransferase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginine catabolic process to ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine catabolic process to ornithine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arginine catabolic process to ornithine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ornithine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ornithine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of primary metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    arginase
    NP_015214.1
    • Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      339944..340945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183925.1 → NP_015214.1  TPA: arginase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Q6, P00812
      UniProtKB/TrEMBL
      A6ZWE0, B3LKW2, B5VT53, C7GJ65, G2WP70, N1NW27
      Conserved Domains (1) summary
      TIGR01229
      Location:16 → 333
      rocF_arginase; arginase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00812.1

    Gene LinkOut

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