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    SLG1 Slg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLG1
    Official Full Name
    Slg1p
    Primary source
    SGD:S000005534
    Locus tag
    YOR008C
    See related
    AllianceGenome:SGD:S000005534; FungiDB:YOR008C; VEuPathDB:YOR008C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HCS77; WSC1
    Summary
    Enables transmembrane signaling receptor activity. Involved in several processes, including Rho protein signal transduction; fungal-type cell wall organization; and pexophagy. Located in cellular bud neck and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLG1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (341278..342414, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sgt2p Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein Neighboring gene Tir4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. Maddi A, et al. PLoS One, 2012. PMID 22879952, Free PMC Article
    2. Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae. Bermejo C, et al. OMICS, 2010 Dec. PMID 20958245
    3. Single-molecule atomic force microscopy reveals clustering of the yeast plasma-membrane sensor Wsc1. Heinisch JJ, et al. PLoS One, 2010 Jun 14. PMID 20559440, Free PMC Article
    4. Measurement of the mechanical behavior of yeast membrane sensors using single-molecule atomic force microscopy. Heinisch JJ, et al. Nat Protoc, 2010 Apr. PMID 20360762
    5. A Three-Dimensional Model of the Yeast Transmembrane Sensor Wsc1 Obtained by SMA-Based Detergent-Free Purification and Transmission Electron Microscopy. Voskoboynikova N, et al. J Fungi (Basel), 2021 Feb 5. PMID 33562593, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The sensors Wsc1 and Mid2 reside in different plasma membrane compartments in Saccharomyces cerevisiae.
      Title: Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling.
    2. wsc1 mutation disrupted biofilm formation in a Flo11p-independent manner.
      Title: The Wsc1p cell wall signaling protein controls biofilm (Mat) formation independently of Flo11p in Saccharomyces cerevisiae.
    3. Study indicates an important role of the extracellular domain of Wsc1 in mediating signal specificity of this sensor to detect cell wall damage.
      Title: Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae.
    4. Data show that Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).
      Title: A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.
    5. endoplasmic reticulum surveillance evasion makes Wsc1p an obligate substrate of Golgi quality control
      Title: Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control.
    6. Chimers of Wsc1 fused to GFP have been employed to show that intracellular and membrane distribution is only dependent on a membrane-anchored cytoplasmic tail.
      Title: Functional analyses of the extra- and intracellular domains of the yeast cell wall integrity sensors Mid2 and Wsc1.
    7. WSC1 is involved in reorganization of the actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae.
      Title: The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae.
    8. Participates in the regulation of a Rho3/4-dependent cellular mechanism, and this is distinct from the role of Wsc1p in the PKC-MAP kinase pathway.
      Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
    9. The dynamic localization of Wsc1p, a sensor of the extracellular wall in yeast, resembles polarized distribution of certain extracellular matrix-sensing integrins through endocytic recycling.
      Title: NPFXD-mediated endocytosis is required for polarity and function of a yeast cell wall stress sensor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection tip HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Slg1p
    NP_014650.1
    • Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      341278..342414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183427.1 → NP_014650.1  TPA: Slg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W274, P54867
      UniProtKB/TrEMBL
      A6ZNL3, B3LJ63, C7GJU5, C8ZHX1, G2WMN8, N1NWF2
      Conserved Domains (1) summary
      smart00321
      Location:22 → 110
      WSC; present in yeast cell wall integrity and stress response component proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54867.1

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