U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MOT3 Mot3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855092, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MOT3
    Official Full Name
    Mot3p
    Primary source
    SGD:S000004674
    Locus tag
    YMR070W
    See related
    AllianceGenome:SGD:S000004674; FungiDB:YMR070W; VEuPathDB:YMR070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ROX7
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cellular hyperosmotic response; negative regulation of ergosterol biosynthetic process; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MOT3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (409154..410626)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Avo2p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD Neighboring gene Tvp18p Neighboring gene DNA-binding protein ABF2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Grishin AV, et al. Genetics, 1998 Jun. PMID 9611199, Free PMC Article
    2. The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity. Kahar P, et al. Metab Eng, 2022 Jul. PMID 35257867
    3. Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Gibney PA, et al. Mol Biol Cell, 2018 Apr 15. PMID 29444955, Free PMC Article
    4. Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Holmes DL, et al. Cell, 2013 Mar 28. PMID 23540696, Free PMC Article
    5. Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3. Klinkenberg LG, et al. Eukaryot Cell, 2005 Apr. PMID 15821125, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity.
      Title: The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity.
    2. Both Mot3 and Msn4 bind directly to some promoter regions osmostress-inducible genes.
      Title: Activator and repressor functions of the Mot3 transcription factor in the osmostress response of Saccharomyces cerevisiae.
    3. Study reports that a prion formed by the Mot3 transcription factor, [MOT3(+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cerevisiae.
      Title: Heritable remodeling of yeast multicellularity by an environmentally responsive prion.
    4. Mot3 and Rox1 are important for growth and modulation of ergosterol levels upon salt stress. Hog1, Mot3, and Rox1 repress ERG gene expression during osmotic stress.
      Title: Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mot3p
    NP_013786.1
    • Transcriptional repressor, activator; role in adjustment to osmotic stress including modulation of mating efficiency; involved in repression of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; ethanol stress increases the frequency of [MOT3+] formation, while hypoxia eliminates [MOT3+]

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      409154..410626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182568.1 → NP_013786.1  TPA: Mot3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP4, P54785
      UniProtKB/TrEMBL
      N1NX95
      Conserved Domains (2) summary
      COG5048
      Location:61 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00019
      Location:348 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54785.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools