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    GIS4 Gis4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIS4
    Official Full Name
    Gis4p
    Primary source
    SGD:S000004465
    Locus tag
    YML006C
    See related
    AllianceGenome:SGD:S000004465; FungiDB:YML006C; VEuPathDB:YML006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in intracellular monoatomic ion homeostasis and intracellular signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GIS4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (256092..258416, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Min4p Neighboring gene DNA-binding transcription factor YAP1 Neighboring gene tRNA-Ser Neighboring gene tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SCFGrr1-mediated ubiquitination of Gis4 modulates glucose response in yeast. La Rue J, et al. J Mol Biol, 2005 Jun 17. PMID 15890364
    2. A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations. González-Ramos D, et al. Biotechnol Biofuels, 2016. PMID 27525042, Free PMC Article
    3. Gis4, a new component of the ion homeostasis system in the yeast Saccharomyces cerevisiae. Ye T, et al. Eukaryot Cell, 2006 Oct. PMID 17030993, Free PMC Article
    4. The pathway by which the yeast protein kinase Snf1p controls acquisition of sodium tolerance is different from that mediating glucose regulation. Ye T, et al. Microbiology (Reading), 2008 Sep. PMID 18757815
    5. Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Balciunas D, et al. Mol Gen Genet, 1999 Dec. PMID 10628841

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gis4 may function in a pathway in which Snf1 plays a specific role in controlling ion homeostasis.
      Title: Gis4, a new component of the ion homeostasis system in the yeast Saccharomyces cerevisiae.
    2. Gis4 may explain the glucose repression defects in carbon source metabolism for the grr1 mutants
      Title: SCFGrr1-mediated ubiquitination of Gis4 modulates glucose response in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gis4p
    NP_013708.1
    • CAAX box containing hypothetical protein; proposed to be involved in the RAS/cAMP signaling pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      256092..258416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182361.1 → NP_013708.1  TPA: Gis4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZG9, Q04233
      UniProtKB/TrEMBL
      A6ZM57, G2WK47, N1P042
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04233.1

    Gene LinkOut

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