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    ITT1 RBR-type E3 ubiquitin transferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ITT1
    Official Full Name
    RBR-type E3 ubiquitin transferase
    Primary source
    SGD:S000004533
    Locus tag
    YML068W
    See related
    AllianceGenome:SGD:S000004533; FungiDB:YML068W; VEuPathDB:YML068W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of translational termination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ITT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (137550..138944)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase Neighboring gene FACT complex subunit POB3 Neighboring gene Erv41p Neighboring gene Sma2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Itt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiae. Urakov VN, et al. BMC Mol Biol, 2001. PMID 11570975, Free PMC Article
    2. TRIADs: a new class of proteins with a novel cysteine-rich signature. van der Reijden BA, et al. Protein Sci, 1999 Jul. PMID 10422847, Free PMC Article
    3. tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Studte P, et al. Mol Microbiol, 2008 Sep. PMID 18657261
    4. The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae. Kodama H, et al. Genes Cells, 2007 May. PMID 17535254
    5. Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast. Moteshareie H, et al. PLoS One, 2018. PMID 30231023, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reports on the finding of two genes, ITT1, an inhibitor of translation termination, and RPS1A, a small ribosomal protein, that when deleted yeast cells exhibit similar metal sensitivity phenotypes to gene deletion strain for URE2.
      Title: Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RBR-type E3 ubiquitin transferase
    NP_013643.1
    • Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      137550..138944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182427.1 → NP_013643.1  TPA: RBR-type E3 ubiquitin transferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZA5, Q04638
      UniProtKB/TrEMBL
      G2WJY7
      Conserved Domains (3) summary
      smart00647
      Location:272 → 334
      IBR; In Between Ring fingers
      cd16551
      Location:179 → 233
      RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
      pfam01485
      Location:385 → 433
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04638.1

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