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    BUD8 Bud8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUD8
    Official Full Name
    Bud8p
    Primary source
    SGD:S000004345
    Locus tag
    YLR353W
    See related
    AllianceGenome:SGD:S000004345; FungiDB:YLR353W; VEuPathDB:YLR353W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular bud site selection and pseudohyphal growth. Located in cellular bud tip; incipient cellular bud site; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUD8 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (834352..836163)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative hydrolase Neighboring gene Lug1p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 Neighboring gene ketol-acid reductoisomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of the Cdc42 GTPase limits the replicative life span of budding yeast. Kang PJ, et al. Mol Biol Cell, 2022 Apr 1. PMID 35044837, Free PMC Article
    2. The role of cell cycle-regulated expression in the localization of spatial landmark proteins in yeast. Schenkman LR, et al. J Cell Biol, 2002 Mar 4. PMID 11877459, Free PMC Article
    3. Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast. Harkins HA, et al. Mol Biol Cell, 2001 Aug. PMID 11514631, Free PMC Article
    4. Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development. Taheri N, et al. EMBO J, 2000 Dec 15. PMID 11118203, Free PMC Article
    5. Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing in Saccharomyces cerevisiae. Vasen G, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152126, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations suggest that the interaction of Rax2p with Bud8p and Bud9p may contribute to the translocation of bipolar landmarks to the correct sites.
      Title: Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells.
    2. Bud8p and Bud9p carry distinct domains for delivery of the proteins to the cell poles, for interaction with the general budding machinery and for association with other cortical tag proteins.
      Title: Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality.
    3. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
      Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bud8p
    NP_013457.1
    • Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      834352..836163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182242.1 → NP_013457.1  TPA: Bud8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ1, P41698, Q06482
      UniProtKB/TrEMBL
      B3RHM2, C8ZDW0, G2WJH1, N1P1P2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41698.2

    Gene LinkOut

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